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Doping, performance-enhancing drugs, and hormones in sport : mechanisms of action and methods of detection

Author: Anthony C Hackney
Publisher: Amsterdam, Netherlands : Elsevier, 2018.
Series: Emerging issues in analytical chemistry.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book examines the biochemistry and bioanalytical aspects of performance-enhancing drugs (PEDs) and other questionable procedures used by athletes to enhance performance, and informs the specialist and non-specialist of emerging knowledge, techniques, underlying science, and current practice of the discipline.
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Anthony C Hackney
ISBN: 9780128134436 0128134437 0128134429 9780128134429
OCLC Number: 1013462261
Description: 1 online resource.
Contents: Foreword; Preface; 1. Overview: Doping in Sport ; History and Current State of the Problem; Prevalence by Sport, Country, Level of Competition; World Anti-Doping Agency and Legal Problems; Ethical Issues of Usage, Sportsmanship, Character; Are There Situations in Which Athletes Can Use PEDs?—Therapeutic Use Exemption; Close-Up: Sports Doping in Ancient Civilization—Nothing New Under the Sun; References; 2. Anabolic Androgenic Steroids ; Treatment of Endocrine Disruptions; The Athletic Drive to Increase Muscle Mass; Intracellular Biochemical and Nuclear Actions; Early Paradoxes and Later Confirmations in Research Findings; Effects of Abuse, Reversible and Nonreversible; Other Anabolic Substances; Close-Up: The Victims of the East German Medal Machine 1970s to 1990s; References; 3. Stimulants; Losing Weight, Staying Awake, Gaining Focus; Staying Athletically Lean and on Task; Neurochemistry; Performance Enhancement Evidence; Speeding and Crashing; Conclusion; Close-Up: Weight Loss and Body Composition—What’s the Difference Between Lean Body Mass, Fat-Free Mass, and Muscle Mass, and Why Do Athletes Care?; 4. Glucocorticoids; Anti-Inflammatory and Pulmonary Actions; Helping Athletes Recover Faster, Breathe Better, and Burn More Fat; Endocrine and Immune Actions; Do They work? Yes, No, and Maybe; Pseudo-Cushing’s Syndrome and Mineralocorticoid Actions?; Conclusion; Close-Up: Primum non nocere—Glucocorticoids and an Ethical Dilemma in Sports Medicine; References; 5. Peptide-Protein Hormones; Offsetting Endocrine Defects and Dysfunctions; Increasing Muscle Mass and Enhancing Oxygen Delivery; Ramping Up Hormone Actions Within Cells; It Works, Within Limits; Acromegaly, Blood Hyperviscosity, and Death; Conclusion; Close-Up: Can Altitude Training Alone Have the Same Effects as Taking EPO?; References; 6. Beta-2 Agonists ; Asthma Prevention and Treatment; Breathing More and Easier Building Muscle in Sport; Bronchodilation Adrenergic Actions and Reactions; Asthmatics, Yes. ! Everyone Else?; Tachycardia, Arrhythmias, Syncope; Conclusion; Close-Up: Use of Inhalers by Asthmatic Athletes—Is This Really Doping?If My Child Uses an Inhaler for Asthma, Is That Doping?; References; 7. Hormone and Metabolic Modulators ; Estrogen and Androgen Modulation in Health and Disease; The Balance Between Gender-Based Hormones; Selective Receptor Modulation Drugs; Contradictions and Ambiguous Evidence; Thrombosis, Embolisms, Hot Flashes, and Hyperandrogenism; Conclusion; Close-Up: Selective Estrogen Receptor Modulators and Exercise as Treatments for Breast Cancer Survivors; References; 8. Narcotics ; In the arms of Morpheus; The Athletic Need to Push Through the Pain; The Opioid System and Pain; Substances that Work too Well; Addiction, Addiction, and Addiction; Close-Up: Pain Management in Athletes—How do Physicians Deal with this Issue when Narcotics are WADA Banned Substances?; References; 9. Beta Blockers; Cardiovascular Modulation and Health; Staying Calm, Cool, and Collected on the Battlefield of Sport; Blocking the Actions of Neurotransmitters and Hormones; Strong Evidence of Performance Enhancement; From Lethargy to Impotence: Undesirable Effects; Close-Up: Sometimes the Consequences of Doping Can Be Quite Severe; References; 10. Athlete Testing, Analytical Procedures, and Adverse Analytical Findings ; WADA Testing Procedures; Biospecimen Analysis Techniques; Strengths and Weaknesses of the Bioanalytical Procedures; Ways in Which Athletes Avoid Detection; What Happens When an Athlete Gets a Positive Test Result?; Close-Up: Fox Guarding the Henhouse; References; 11. The Future of Performance Enhancement in Sport ; Can Prevention and Detection Deter Doping?; Education of Athletes: Is That Enough?; Staying Ahead of the Doping Athlete: Is it Possible?; Genetic Doping: Is it the Future?; Should Doping be Legalized and Regulated?; Binary Gender Constructs and the Future; What’s Next?; Close-Up: Women Athletes—Taller, Faster, Stronger, and Hyperandrogenism; References
Series Title: Emerging issues in analytical chemistry.
Responsibility: Anthony C. Hackney.

Abstract:

This book examines the biochemistry and bioanalytical aspects of performance-enhancing drugs (PEDs) and other questionable procedures used by athletes to enhance performance, and informs the specialist and non-specialist of emerging knowledge, techniques, underlying science, and current practice of the discipline.

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