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Drinking Water and Health, Volume 8 : Pharmacokinetics in Risk Assessment.

Author: National Research Council Staff; Safe Drinking Water Committee
Publisher: Washington : National Academies Press, 1900.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Staff, National Research Council.
Drinking Water and Health, Volume 8 : Pharmacokinetics in Risk Assessment.
Washington : National Academies Press, ©1900
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: National Research Council Staff; Safe Drinking Water Committee
ISBN: 9780309557696 0309557690
OCLC Number: 923269214
Notes: ""Lungs and Skin Administration""
Description: 1 online resource (512 pages)
Contents: ""Pharmacokinetics in Risk Assessment""; ""Copyright""; ""PREFACE""; ""Contents""; ""PART I INTRODUCTION: THE PROBLEM AND AN APPROACH ""; ""Risk Assessment: Historical Perspectives""; ""References""; ""Tissue Dosimetry in Risk Assessment, or What's the Problem Here Anyway?""; ""INTRODUCTION""; ""A DOSE OF WHAT?""; ""ISN'T THIS VOLUME ABOUT PHARMACOKINETICS?""; ""GENOTOXIC CARCINOGENS""; ""PARENT CHEMICAL""; ""STABLE METABOLITES""; ""REACTIVE, NONISOLATABLE METABOLITES""; ""INTERCALATING AGENTS""; ""EPIGENETIC CARCINOGENS""; ""SUMMARY""; ""References""; ""PART II MATHEMATICAL MODELING "" ""Modeling: An Introduction""""References""; ""Physiologically Based Pharmacokinetic Modeling""; ""INTRODUCTION""; ""BIOLOGICAL BASIS OF PHYSIOLOGICAL PHARMACOKINETICS""; ""DEVELOPMENT OF MODELS""; ""CHOICE OF COMPARTMENTS""; ""BASIC MASS BALANCES""; ""Mass Balance: Blood Pool""; ""Mass Balance: Tissue Region i""; ""SIMPLIFICATIONS OF MASS BALANCES""; ""Examples""; ""DISCUSSION""; ""FUTURE RESEARCH NEEDS""; ""References""; ""PART III GENERALIZATIONS AND EXTRAPOLATIONS ""; ""Allometry: Body Size Constraints in Animal Design""; ""INTRODUCTION""; ""SIZE, DESIGN, AND PHARMACOKINETICS"" ""Aerobic Energetics of Muscle In Vivo""""Conflict of Physiological and Chronological Time""; ""Species Extrapolations, Physiological Time, and Pharmacokinetics""; ""CONCLUSIONS""; ""SUMMARY""; ""References""; ""Prediction of In Vivo Parameters of Drug Metabolism and Distribution from In Vitro Studies""; ""IN VITRO PREDICTION OF IN VIVO DRUG METABOLISM""; ""IN VITRO PREDICTION OF IN VIVO DRUG BINDING AND DISTRIBUTION""; ""CONCLUSION""; ""References""; ""Dose, Species, and Route Extrapolation: General Aspects""; ""DIFFERENT PROBLEMS AND OBJECTIVES, DIFFERENT MODELS""; ""Different Mechanisms"" ""GENERAL PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS""""Simplification of Models""; ""Rates of Formation of Complexes""; ""Diffusional Barriers and Modified Fick's Law""; ""Simple PB-PK Models""; ""Basic Parameters fu and R""; ""Nonlinear Kinetics and Lost Concepts""; ""INTERFACE BETWEEN PB-PK MODELS AND CLEARANCES""; ""Organ Availabilities (F), Extraction Ratios (E), and Clearances (CL)""; ""Physiologically Based Linear Compartmental Pharmacokinetic Models""; ""Validity of the Assumption of Virtual Steady State""; ""Calculation of Other Compartmental Model Parameters"" ""Approximations of Terminal Half-Lives""""Approximate Time Required to Approach Steady State""; ""LINEAR PHARMACOKINETIC SYSTEMS""; ""Total Body Clearance""; ""Importance of the Unbound Concentration of Substances""; ""Classification of Organs; Routes of Administration""; ""Non-First-Pass, Nonelimination Organs""; ""Range of Maximum and Minimum Unbound Concentrations in Nonelimination Organs and Repetitive Administration""; ""Non-First-Pass, Elimination Organs""; ""FIRST-PASS, NONELIMINATION ORGANS""; ""First-Pass, Elimination Organs""; ""ROUTE-TO-ROUTE EXTRAPOLATION""

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