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Drug bioavailability : estimation of solubility, permeability, absorption and bioavailability

Author: Han van de Waterbeemd; Hans Lennernäs; Per Artursson
Publisher: Weinheim : Wiley-VCH, ©2003.
Series: Methods and principles in medicinal chemistry, v. 18.
Edition/Format:   Print book : Document   Computer File : EnglishView all editions and formats
Database:WorldCat
Summary:

The preoral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. Since many pharmacologically active substances are  Read more...

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Material Type: Document, Internet resource
Document Type: Book, Computer File, Internet Resource
All Authors / Contributors: Han van de Waterbeemd; Hans Lennernäs; Per Artursson
ISBN: 9783527304387 352730438X
OCLC Number: 50877929
Description: xxiv, 579 pages : illustrations ; 25 cm.
Contents: Physico-chemical approaches to drug absorption / Han van de Waterbeemd --
High-throughput measurement of log D and pKa / Dr. John E.A. Comer --
High-throughput measurement of permeability profiles --
Alex Avdeef --
Caco-2 and emerging alternatives for prediction of intestinal drug transport : a general overview / Per Artursson and Staffan Tavelin --
Cell cultures in drug discovery : an industrial perspective / Anna-Lena Ungell and Johan Karlsson --
Use of animals for the determination of absorption and bioavailability / Chris Logan --
In vivo permeability studies in the gastrointestinal tract of humans / Niclas Petri and Hans Lennernäs --
Gastrointestinal dissolution and absorption of drugs / Gladys E. Granero, Chandrasekharan Ramachandran, and Gordon L. Amidon --
Aqueous solubility in discovery, chemistry, and assay changes / Chris Lipinski --
Factors influencing the water solubilities of crystalline drugs / James W. McFarland, Chau M. Du, and Alex Avdeef --
Transporters in the GI tract / Ho-Chul Shin [and others] --
Hepatic transport / Hiroshi Suzuki and Yuichi Sugiyama --
The importance of gut wall metabolism in determining drug bioavailability / Kevin Beaumont --
Modified cell lines / Charles L. Crespi --
Intestinal absorption : the role of polar surface area / Per Artursson and Christel A.S. Bergström --
Calculated molecular properties and multivariate statistical analysis in absorption prediction / Ulf Norinder and Markus Haeberlein --
VOLSURF : a tool for drug ADME-properties prediction / Gabriele Cruciani [and others] --
Simulation of absorption, metabolism, and bioavailability / Michael B. Bolger [and others] --
Prediction of bioavailability / Arun K. Mandagere and Barry Jones --
Towards P-glycoprotein structure-activity relationships / Anna Seelig [and others] --
Application of the biopharmaceutical classification system now and in the future / Bertil Abrahamsson and Hans Lennernäs --
Prodrugs / Bente Steffansen, Anne Engelbrecht Thomsen, and Sven Frokjaer --
Modern delivery strategies : physiological considerations for orally administered medications / Clive G. Wilson.
Series Title: Methods and principles in medicinal chemistry, v. 18.
Responsibility: edited by Han van de Waterbeemd, Hans Lennernäs and Per Artursson.
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"...this book would make a valuable resource for scientists working in drug discovery and early drug development..." (Pharmaceutical Research, June 2004) "This monograph is without a doubt the most Read more...

 
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