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Drug class review. Direct renin inhibitors, angiotensin converting enzyme inhibitors, and angiotensin II receptor blockers : final report

Author: Susan L NorrisJessica WeinsteinKim PetersonSujata ThakurtaMarian S McDonaghAll authors
Publisher: Portland, Oregon : Oregon Health & Science University, 2010.
Series: Drug class reviews.
Edition/Format:   eBook : Document : English
Summary:
The renin-angiotensin system is a complex biologic system between the heart, brain, blood vessels, and kidneys that leads to the production of biologically active agents, including angiotensin I and II and aldosterone, which act together to impact a variety of bodily functions including blood vessel tone, sodium balance, and glomerular filtration pressure. The multiple and varied effects of these agents allows the  Read more...
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Details

Genre/Form: Review
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Susan L Norris; Jessica Weinstein; Kim Peterson; Sujata Thakurta; Marian S McDonagh; Drug Effectiveness Review Project,; Oregon Health & Science University. Evidence-based Practice Center,; Oregon Health & Science University,
OCLC Number: 867073965
Notes: "January 2010."
Title from PDF title page.
Description: 1 online resource (1 PDF file (144 pages)) : illustrations.
Series Title: Drug class reviews.
Other Titles: Direct renin inhibitors, angiotensin converting enzyme inhibitors, and angiotensin II receptor blockers
Responsibility: Susan Norris, Jessica Weinstein, Kimberly Peterson, Sujata Thakurta ; Drug Effectiveness Review Project, Marian McDonagh, prinicipal investigator ; Oregon Evidence-based Practice Center, Mark Helfand, director ; Oregon Health & Science University.

Abstract:

The renin-angiotensin system is a complex biologic system between the heart, brain, blood vessels, and kidneys that leads to the production of biologically active agents, including angiotensin I and II and aldosterone, which act together to impact a variety of bodily functions including blood vessel tone, sodium balance, and glomerular filtration pressure. The multiple and varied effects of these agents allows the renin-angiotensin system to play a wide role in the pathology of hypertension, cardiovascular health, and renal function. Our ability to begin to intervene upon the complex cycle of hormone and other biochemical agent production within the renin-angiotensin system began with the advent of the first orally active ACE-I (angiotensin converting enzyme inhibitor), captopril, in 1981. AIIRAs (angiotensin II receptor blockers) were developed as an alternative to ACE-I, and block the interaction between angiotensin II and the angiotensin receptor. Losartan, the first commercially available AIIRA, was approved for clinical use in 1995. The goal of this report is to compare the effectiveness and harms between aliskiren and placebo and between AIIRAs and ACEIs in the treatment of diagnosed coronary heart disease, hypertension, left ventricular dysfunction, heart failure, nondiabetic chronic kidney disease, or diabetic nephropathy.

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Primary Entity

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