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Drug delivery nanosystems for biomedical applications

Author: Chandra Prakash Sharma
Publisher: Amsterdam, Netherlands : Elsevier, [2018] ©2018
Series: Micro & nano technologies.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: (OCoLC)1007083036
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Chandra Prakash Sharma
ISBN: 9780323509237 0323509231
OCLC Number: 1049799989
Description: 1 online resource.
Contents: Front Cover; Drug Delivery Nanosystems for Biomedical Applications; Copyright; Contents; Contributors; Chapter 1: Drug delivery nanosystems-An introduction; 1.1 Foreword; 1.2 Different Forms of Drug Delivery Vehicles; 1.2.1 Colloidal Nanoparticles and Nanocapsules; 1.2.2 Nonspherical and Inorganic Nanoparticles; 1.2.3 Polymeric Micelles and Other Nanoparticles; 1.3 Classification of Drug Delivery Nanosystems; 1.4 Versatality to the Target Site; 1.5 Perspectives; References; Chapter 2: Blood compatibility of nanomaterials; 2.1 Introduction; 2.2 Blood Compatibility: Background 2.3 Macro-materials2.4 Nanomaterials; 2.4.1 Platelet Adhesion/Aggregation, Plasma Coagulation, Complement Activation, Hemolysis; 2.4.2 Protein Adsorption: The Corona; Acknowledgments; References; Chapter 3: Safety and toxicity concerns of nanosystems; 3.1 Introduction; 3.2 Nanoparticle Exposure; 3.2.1 Occupational Exposure; 3.2.2 Environmental Exposure; 3.2.3 Consumer Exposure; 3.3 Routes of Exposures; 3.3.1 Inhalation; 3.3.2 Transdermal Absorption; 3.3.3 Ingestion; 3.3.4 Injection/Parenteral Administration; 3.4 Bio-Nano Interactions-Cellular and Molecular Levels; 3.5 Nanoparticle Uptake 3.6 Protein Corona3.7 Membrane Integrity; 3.8 Cytoskeletal Arrangement; 3.9 Organellar Dysfunction; 3.10 Apoptosis; 3.11 Reactive Oxygen Species and Oxidative Stress; 3.12 Genotoxicity; 3.13 Conclusion; Acknowledgments; References; Chapter 4: Pharmaceutical perspectives of selection criteria and toxicity profiling of nanotheranostic agents; 4.1 Introduction; 4.2 Critical Gap That Nanotheranostics Fills in Therapeutics; 4.3 Features and Concerns of Nanoparticle for Nanotheranostic Design 4.3.1 Structural and Electronic Properties of Nanoparticles at Nanoscale and Its Influence on Biological Functions4.3.2 Macroscale Dispersibility Properties of Nanoparticles Influencing the Biological Functions; 4.3.3 Dissolution and Disintegration Properties of Nanoparticles Influencing Biological Action; 4.4 Importance of Developing a Need-Based Selection Criteria; 4.4.1 Nature and Properties of Target Site for Need-Based Selection Criteria; 4.4.2 Types of Nanoconstructs From a Need-Based Selection Criteria; 4.5 Safety Aspects of Theranostic Agents and Toxicity Profiling 4.5.1 Safety Aspects of Nanotheranostics From Biological Perspective4.5.2 Safety at Cellular Level; 4.5.3 Safety at Tissue Level; 4.5.4 Toxicity at the Level of Blood; 4.5.5 Safety at Organ Level; 4.5.6 Safety at Body Level; 4.5.7 Safety Aspects of Nanotheranostics From Nanotheranostic Perspective; Structure-dependent toxicities of nanotheranostics; Dose-dependent toxicity; Advancements in toxicity screening; Marketing perspectives and clinical applications; 4.6 Conclusion; Acknowledgment; References; Chapter 5: Nanosystems and antibacterial applications; 5.1 Introduction
Series Title: Micro & nano technologies.
Responsibility: edited by Chandra Prakash Sharma.

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