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Drug delivery : principles and applications

Author: Binghe Wang; Longqin Hu; Teruna Siahaan
Publisher: Hoboken, New Jersey : John Wiley & Sons Inc., 2016.
Edition/Format:   eBook : Document : English : Second editionView all editions and formats
Summary:

Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the  Read more...

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Genre/Form: Electronic books
Additional Physical Format: Print version:
Drug delivery.
Hoboken, New Jersey : John Wiley & Sons Inc., 2016
(DLC) 2015039604
(DNLM)101686042
(OCoLC)926623491
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Binghe Wang; Longqin Hu; Teruna Siahaan
ISBN: 9781118833322 1118833325 1118833368 9781118833360
OCLC Number: 926623506
Notes: Revision of: Drug delivery / Binghe Wang, Teruna Siahaan, Richard Soltero. 2005.
Description: 1 online resource
Contents: <P>List of Contributors</p> <p>Preface</p> <p><b>1 Factors that impact the developability of drug candidates<br /> </b><i>Chao Han and Binghe Wang</i></p> <p>1.1. Challenges facing the pharmaceutical industry</p> <p>1.2. Factors that Impact Developability</p> <p>1.3. Commercial goal</p> <p>1.3.1. The Chemistry Efforts</p> <p>1.3.2. Biotechnology in the Discovery of Medicine</p> <p>1.3.3. Target Validation in Animal Models</p> <p>1.3.4. Pharmacokinetics and Drug Metabolism</p> <p>1.3.5. Preparation for Pharmaceutical Products</p> <p>1.3.6. Remarks on Developability</p> <p>1.4. Drug Delivery Factors that Impact Developability</p> <p>References</p> <p><b>2. Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery<br /> </b><i>Paul Kiptoo, Anna M. Calcagno, and Teruna J. Siahaan</i></p> <p>2.1. Introduction</p> <p>2.2. Physiological Barriers to Drug Delivery</p> <p>2.2.1. Paracellular Pathway</p> <p>2.2.2. Transcellular Pathway</p> <p>2.3. Biochemical Barriers to Drug Delivery</p> <p>2.3.1. Metabolizing Enzymes</p> <p>2.3.2. Transporters and Efflux Pumps</p> <p>2.4. Chemical Barriers to Drug Delivery</p> <p>2.4.1. Hydrogen-Bonding Potential</p> <p>2.4.2. Other Properties</p> <p>2.5. Drug Modifications to Enhance Transport Across Biological Barriers</p> <p>2.5.1. Prodrugs and Structural Modifications</p> <p>2.5.2. Formulations</p> <p>2.6. Conclusions</p> <p>References</p> <p><b>3 Physicochemical Properties, Formulation, and Drug Delivery<br /> </b><i>Dewey H. Barich, Mark T. Zell, and Eric J. Munson</i></p> <p>3.1. Introduction</p> <p>3.2. Physicochemical Properties</p> <p>3.2.1. Solubility</p> <p>3.2.2. Stability</p> <p>3.3. Formulations</p> <p>3.3.1. Processing steps</p> <p>3.3.2. Influence of physicochemical properties on drugs in formulations</p> <p>3.3.3. Other issues</p> <p>3.4. Drug Delivery</p> <p>3.4.1. Duration of Release</p> <p>3.4.2. Site of Administration</p> <p>3.4.3. Methods of Administration</p> <p>3.5. Conclusion</p> <p>References</p> <p><b>4 Targeted Bioavailability: A Fresh Look at Pharmacokinetics and Pharmacodynamics Issues in Drug Discovery and Development<br /> </b><i>Christine Xu</i></p> <p>4.1. Introduction</p> <p>4.2. Target bioavailability</p> <p>4.3. Drug delivery trends and targets related to pharmacokinetics and pharmacodynamics</p> <p>4.4. Pharmacokinetics (PK) --
pharmacodynamics (PD) in drug discovery and development</p> <p>4.5. Source of variability of drug response</p> <p>4.6. Recent development and issues of bio-analytical methodology</p> <p>4.7. Mechanistic PK-PD models</p> <p>4.8. Summary</p> <p>References</p> <p><b>5 The Role of Transporters in Drug Delivery and Excretion<br /> </b><i>Marilyn E. Morris and Xiaowen Guan</i></p> <p>5.1. Introduction</p> <p>5.2. Drug Transport in absorption and excretion.</p> <p>5.2.1. Intestinal transport</p> <p>5.2.2. Hepatic Transport</p> <p>5.2.3. Renal Transport</p> <p>5.2.4. Blood-brain barrier transport</p> <p>5.3. ABC (ATP-binding cassette) transporter family</p> <p>5.3.1. P-glycoprotein (ABCB1)</p> <p>5.3.2. Multidrug Resistance-associated Proteins (ABCC)</p> <p>5.3.3. Breast Cancer Resistance Protein (ABCG2)</p> <p>5.3.4. Other ABC transporters</p> <p>5.4. SLC (solute carrier) transporter family</p> <p>5.4.1. Organic Anion Transporting Polypeptides (SLCO)</p> <p>5.4.2. Organic Anion Transporters (SLC22A)</p> <p>5.4.3. Organic Cation Transporters (SLC22)</p> <p>5.4.4. Multidrug and Toxin Extrusion Transporters (SLC47A)</p> <p>5.4.5. Monocarboxylate Transporters (SLC16 and SLC5)</p> <p>5.4.6. Peptide Transporters (SLC15A)</p> <p>5.4.7. Other SLC transporters</p> <p>5.5. Conclusions</p> <p>References</p> <p><b>6 Intracellular delivery and disposition of small molecular weight drugs<br /> </b><i>Jeffrey Krise</i></p> <p>6.1 Introduction</p> <p>6.2. The relationship between the intracellular distribution of a drug and its activity</p> <p>6.3.
Responsibility: edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan.

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List of Contributors

Preface

1 Factors that impact the developability of drug candidates
Chao Han and Binghe Wang

1.1. Challenges facing the pharmaceutical industry

1.2. Factors that Impact Developability

1.3. Commercial goal

1.3.1. The Chemistry Efforts

1.3.2. Biotechnology in the Discovery of Medicine

1.3.3. Target Validation in Animal Models

1.3.4. Pharmacokinetics and Drug Metabolism

1.3.5. Preparation for Pharmaceutical Products

1.3.6. Remarks on Developability

1.4. Drug Delivery Factors that Impact Developability

References

2. Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery
Paul Kiptoo, Anna M. Calcagno, and Teruna J. Siahaan

2.1. Introduction

2.2. Physiological Barriers to Drug Delivery

2.2.1. Paracellular Pathway

2.2.2. Transcellular Pathway

2.3. Biochemical Barriers to Drug Delivery

2.3.1. Metabolizing Enzymes

2.3.2. Transporters and Efflux Pumps

2.4. Chemical Barriers to Drug Delivery

2.4.1. Hydrogen-Bonding Potential

2.4.2. Other Properties

2.5. Drug Modifications to Enhance Transport Across Biological Barriers

2.5.1. Prodrugs and Structural Modifications

2.5.2. Formulations

2.6. Conclusions

References

3 Physicochemical Properties, Formulation, and Drug Delivery
Dewey H. Barich, Mark T. Zell, and Eric J. Munson

3.1. Introduction

3.2. Physicochemical Properties

3.2.1. Solubility

3.2.2. Stability

3.3. Formulations

3.3.1. Processing steps

3.3.2. Influence of physicochemical properties on drugs in formulations

3.3.3. Other issues

3.4. Drug Delivery

3.4.1. Duration of Release

3.4.2. Site of Administration

3.4.3. Methods of Administration

3.5. Conclusion

References

4 Targeted Bioavailability: A Fresh Look at Pharmacokinetics and Pharmacodynamics Issues in Drug Discovery and Development
Christine Xu

4.1. Introduction

4.2. Target bioavailability

4.3. Drug delivery trends and targets related to pharmacokinetics and pharmacodynamics

4.4. Pharmacokinetics (PK) -- pharmacodynamics (PD) in drug discovery and development

4.5. Source of variability of drug response

4.6. Recent development and issues of bio-analytical methodology

4.7. Mechanistic PK-PD models

4.8. Summary

References

5 The Role of Transporters in Drug Delivery and Excretion
Marilyn E. Morris and Xiaowen Guan

5.1. Introduction

5.2. Drug Transport in absorption and excretion.

5.2.1. Intestinal transport

5.2.2. Hepatic Transport

5.2.3. Renal Transport

5.2.4. Blood-brain barrier transport

5.3. ABC (ATP-binding cassette) transporter family

5.3.1. P-glycoprotein (ABCB1)

5.3.2. Multidrug Resistance-associated Proteins (ABCC)

5.3.3. Breast Cancer Resistance Protein (ABCG2)

5.3.4. Other ABC transporters

5.4. SLC (solute carrier) transporter family

5.4.1. Organic Anion Transporting Polypeptides (SLCO)

5.4.2. Organic Anion Transporters (SLC22A)

5.4.3. Organic Cation Transporters (SLC22)

5.4.4. Multidrug and Toxin Extrusion Transporters (SLC47A)

5.4.5. Monocarboxylate Transporters (SLC16 and SLC5)

5.4.6. Peptide Transporters (SLC15A)

5.4.7. Other SLC transporters

5.5. Conclusions

References

6 Intracellular delivery and disposition of small molecular weight drugs
Jeffrey Krise

6.1 Introduction

6.2. The relationship between the intracellular distribution of a drug and its activity

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