skip to content
Drug design : methodology, concepts, and mode-of-action Preview this item
ClosePreview this item
Checking...

Drug design : methodology, concepts, and mode-of-action

Author: Gerhard Klebe
Publisher: Berlin : Springer 2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Klebe, Gerhard.
Drug design
(OCoLC)851184572
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Gerhard Klebe
ISBN: 9783642179075 364217907X 3642179061 9783642179068
OCLC Number: 857279797
Description: 1 online resource (720 pages) : color illustrations
Contents: Part I: Fundamentals in Drug Research --
Drug Research: Yesterday, Today, and Tomorrow --
In the Beginning, There Was Serendipity --
Classical Drug Research --
Protein-Ligand Interactions as the Basis for Drug Action --
Optical Activity and Biological Effect --
Part II: The Search for the Lead Structure. The Classical Search for Lead Structures --
Screening Technologies for Lead Structure Discovery --
Optimization of Lead Structures --
Designing Prodrugs --
Peptidomimetics --
Part III: Experimental and Theoretical Methods. Combinatorics: Chemistry with Big Numbers --
Gene Technology in Drug Research --
Experimental Methods of Structure Determination --
Three-Dimensional Structure of Biomolecules --
Molecular Modeling --
Conformational Analysis --
Part IV: Structure-Activity Relationships and Design Approaches. Pharmacophore Hypotheses and Molecular Comparisons --
Quantitative Structure-Activity Relationships --
From In Vitro to In Vivo: Optimization of ADME and Toxicology Properties --
Protein Modeling and Structure-Based Drug Design --
A Case Study: Structure-Based Inhibitor Design for tRNA-Guanine Transglycosylase --
Part V: Drugs and Drug Action: Successes of Structure-Based Design. How Drugs Act: Concepts for Therapy --
Inhibitors of Hydrolases with an Acyl-Enzyme Intermediate --
Aspartic Protease Inhibitors --
Inhibitors of Hydrolyzing Metalloenzymes --
Transferase Inhibitors --
Oxidoreductase Inhibitors --
Agonists and Antagonists of Nuclear Receptors --
Agonists and Antagonists of Membrane-Bound Receptors --
Ligands for Channels, Pores, and Transporters --
Ligands for Surface Receptors --
Biologicals: Peptides, Proteins, Nucleotides, and Macrolides as Drugs.
Other Titles: Wirkstoffdesign.
Responsibility: Gerhard Klebe.
More information:

Abstract:

Drug Design  Read more...

Reviews

Editorial reviews

Publisher Synopsis

Aus den Rezensionen: "... stellt eine sehr gute Informationsquelle fur einen Diplomanden oder Doktoranden der pharmazeutischen Chemie dar, der in diesem Bereich arbeitet und am Beginn seiner Read more...

 
User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.

Similar Items

Related Subjects:(2)

Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


<http://www.worldcat.org/oclc/857279797>
bgn:translationOfWork
library:oclcnum"857279797"
library:placeOfPublication
rdf:typeschema:Book
rdf:typeschema:MediaObject
rdf:valueUnknown value: dct
schema:about
schema:about
schema:about
schema:about
schema:bookFormatschema:EBook
schema:creator
schema:datePublished"2013"
schema:description"Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology in drug design, omics-technologies computational methods experimental techniques of structure determinationmultiple examples on mode of action of current drugs, ADME-tox properties in drug development, QSAR methods, combinatorial chemistry, biologicals, ribosome, targeting protein-protein interfaces."@en
schema:exampleOfWork
schema:genre"Electronic books"@en
schema:inLanguage"en"
schema:name"Drug design : methodology, concepts, and mode-of-action"@en
schema:url
schema:workExample
schema:workExample
schema:workExample
wdrs:describedby

Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.