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Drug discovery research : new frontiers in the post-genomic era

Author: Ziwei Huang
Publisher: Hoboken, N.J. : Wiley-Interscience, ©2007.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
Provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical discovery in the post-genomics era.
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Genre/Form: Online-Publikation
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Ziwei Huang
ISBN: 9780471672005 0471672009 9780470131862 0470131861
OCLC Number: 85498729
Description: xix, 521 pages, [16] pages of plates : illustrations (some color) ; 25 cm
Contents: Molecular docking and structure-based design / P. Therese Lang [and others] --
Recent advances in drug discovery research using structure-based virtual screening techniques : examples of success for diverse protein targets / Sutapa Ghosh [and others] --
Virtual screening in drug discovery / Malcolm J. McGregor, Zhaowen Luo, and Xuliang Jiang --
Computer-aided drug design / Grace Shiahuy Chen and Ji-Wang Chern --
Focused library design based on hit and target structures : method and application in drug discovery / Weiliang Zhu [and others]. Beyond natural products : synthetic analogs of bryostatin 1 / Paul A. Wender [and others] --
The promises and pitfalls of small-molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG) / Amanda C. Nottbohm and Paul J. Hergenrother --
Cyclic ADP-ribose analogues with minimal structure : synthesis and calcium-release activity / Lihe Zhang and Andreas H. Guse --
Evaluation of neuroimmunophilin ligands / Junhai Xiao, Aihua Nie, and Song Li --
Chiral drugs and the associated asymmetric synthesis / Jiange Zhang and Guoqiang Lin. Alpha-helix mimetics in drug discovery / Hang Yin, Gui-In Lee, and Andrew D. Hamilton --
Basic and translational research of chemokine ligands and receptors and development of novel therapeutics / Won-Tak Choi [and others] --
Research progress in protein post-translational modification / Jia Hu, Yanting Guo, and Yanmei Li --
Controlled release of antibiotics encapsulated in nanoporous sol-gel materials with tunable pore parameters / Houping Yin, Laura Zheng, and Yen Wei --
Retinoic acid and arsenic trioxide treatment in acute promyelocytic leukemia : a model of oncoprotein targeted therapy / Jian-Hua Tong, Sai-Juan Chen, and Zhu Chen. 2-chlorodeoxyadenosine (cladribine) : rational development of a novel chemotherapeutic agent / Howard B. Cottam and Dennis A. Carson --
Apoptosis-based drug discovery for cancer / John C. Reed [and others] --
Mechanism-based development of memantine as a therapeutic agent in treating Alzheimer's disease and other neurologic disorders : low-affinity, uncompetitive antagonism with fast off-rate / Huei-Sheng Vincent Chen and Stuart A. Lipton --
Bridging bench to clinic : roles of animal models for post-genomics drug discovery on metabolic diseases / Chi-Wai Wong and Ling Chen --
Stem cell research and applications for human therapies / Prithi Rajan [and others].
Responsibility: edited by Ziwei Huang.
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Abstract:

This book explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences such as pharmacogenomics, chemical genomics, chemical biology, structural  Read more...

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"A valuable resource for scientists ... Chapters in each section are filled with in-depth biological and chemical data and, importantly, include worked examples of drugs identified from these Read more...

 
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