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Détails
| Type d’ouvrage : | Ressource Internet |
|---|---|
| Format : | Livre, Ressource Internet |
| Tous les auteurs / collaborateurs : |
Ziwei Huang |
| ISBN : | 9780471672005 0471672009 |
| Numéro OCLC : | 85498729 |
| Description : | xix, 521 p., [16] p. of plates : ill. (some col.) ; 25 cm. |
| Contenu : | Molecular docking and structure-based design / P. Therese Lang ... [et al.] -- Recent advances in drug discovery research using structure-based virtual screening techniques : examples of success for diverse protein targets / Sutapa Ghosh ... [et al.] -- Virtual screening in drug discovery / Malcolm J. McGregor, Zhaowen Luo, and Xuliang Jiang -- Computer-aided drug design / Grace Shiahuy Chen and Ji-Wang Chern -- Focused library design based on hit and target structures : method and application in drug discovery / Weiliang Zhu ... [et al.]. Beyond natural products : synthetic analogs of bryostatin 1 / Paul A. Wender ... [et al.] -- The promises and pitfalls of small-molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG) / Amanda C. Nottbohm and Paul J. Hergenrother -- Cyclic ADP-ribose analogues with minimal structure : synthesis and calcium-release activity / Lihe Zhang and Andreas H. Guse -- Evaluation of neuroimmunophilin ligands / Junhai Xiao, Aihua Nie, and Song Li -- Chiral drugs and the associated asymmetric synthesis / Jiange Zhang and Guoqiang Lin. Alpha-helix mimetics in drug discovery / Hang Yin, Gui-In Lee, and Andrew D. Hamilton -- Basic and translational research of chemokine ligands and receptors and development of novel therapeutics / Won-Tak Choi ... [et al.] -- Research progress in protein post-translational modification / Jia Hu, Yanting Guo, and Yanmei Li -- Controlled release of antibiotics encapsulated in nanoporous sol-gel materials with tunable pore parameters / Houping Yin, Laura Zheng, and Yen Wei -- Retinoic acid and arsenic trioxide treatment in acute promyelocytic leukemia : a model of oncoprotein targeted therapy / Jian-Hua Tong, Sai-Juan Chen, and Zhu Chen. 2-chlorodeoxyadenosine (cladribine) : rational development of a novel chemotherapeutic agent / Howard B. Cottam and Dennis A. Carson -- Apoptosis-based drug discovery for cancer / John C. Reed ... [et al.] -- Mechanism-based development of memantine as a therapeutic agent in treating Alzheimer's disease and other neurologic disorders : low-affinity, uncompetitive antagonism with fast off-rate / Huei-Sheng Vincent Chen and Stuart A. Lipton -- Bridging bench to clinic : roles of animal models for post-genomics drug discovery on metabolic diseases / Chi-Wai Wong and Ling Chen -- Stem cell research and applications for human therapies / Prithi Rajan ... [et al.]. |
| Responsabilité : | edited by Ziwei Huang. |
| Plus d’informations : |
Résumé :
This book explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences such as pharmacogenomics, chemical genomics, chemical biology, structural genomics, drug discovery, biophysics and bioengineering with various chapters contributed by experts in respective fields.
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Critiques
Critiques éditoriales
Synopsis de l’éditeur
"A valuable resource for scientists ... Chapters in each section are filled with in-depth biological and chemical data and, importantly, include worked examples of drugs identified from these approaches." (The Biochemist, October 2008) "..the book achieves the objective of the Editor in providing a useful tool and reference for scientists concerned with state-of-the-art postgenomic drug discovery...this book will be of interest to medicinal chemistry, as well as to other concerned with developing new drug products." (Journal of Medicinal Chemistry, January 2008) Lire la suite...
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