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Drug-drug interactions

Author: A David Rodrigues
Publisher: New York : Informa Healthcare, ©2008.
Series: Drugs and the pharmaceutical sciences, v. 179.
Edition/Format:   Print book : English : 2nd edView all editions and formats
Summary:
Helping researchers predict drug interactions in a more accurate and effective manner, this text covers every critical aspect of metabolism-based drug-drug interactions, including preclinical, clinical, toxicological, regulatory, and marketing perspectives by leaders in their respective fields.
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Additional Physical Format: Online version:
Drug-drug interactions.
New York : Informa Healthcare, ©2008
(OCoLC)607811073
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: A David Rodrigues
ISBN: 9780849375934 0849375932
OCLC Number: 166278677
Description: xi. 744 pages : illustrations ; 24 cm.
Contents: Introducing pharmacokinetic and pharmacodynamic concepts / Malcolm Rowland --
In vitro enzyme kinetics applied to drug-metabolizing enzymes / Kenneth R. Korzekwa --
Human cytochromes P450 and their role in metabolism-based drug-drug interactions / Stephen E. Clarke and Barry C. Jones --
UDP-glucuronosyltransferases / Rory P. Remmel, Jin Zhou, and Upendra A. Argikar --
Drug-drug interactions involving the membrane transport process / Hiroyuki Kusuhara and Yuichi Sugiyama --
In vitro models for studying induction of cytochrome P450 enzymes / Jose M. Silva and Deborah A. Nicoll-Griffith --
In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs (reaction phenotyping) with emphasis on cytochrome P450 / Brian W. Ogilvie [and others] --
The role of P-glycoprotein in drug disposition: significance to drug development / Matthew D. Troutman [and others] --
Cytochrome P450 protein modeling and ligand docking / K. Anton Feenstra, Chris de Graaf, and Nico P.E. Vermeulen --
Role of the gut mucosa in metabolically based drug-drug interactions / Kenneth E. Thummel, Danny D. Shen, and Nina Isoherannen --
Mechanism-based inhibition of human cytochromes P450: in vitro kinetics and in vitro-in vivo correlations / Xin Zhang, David R. Jones, and Stephen D. Hall --
Transporter-mediated drug interactions: molecular mechanisms and clinical implications / Jiunn H. Lin --
Metabolism and transport drug interaction database: a web-based research and analysis tool / Houda Hachad, Isabelle Ragueneau-Majlessi, and René H. Levy --
In vivo probes for studying induction and inhibition of cytochrome P450 enzymes in humans / Grant R. Wilkinson --
Drug-drug interactions: clinical perspective / David J. Greenblatt and Lisa L. von Moltke --
An integrated approach to assessing drug-drug interactions: a regulatory perspective / Shiew-Mei Huang, Lawrence J. Lesko, and Robert Temple --
Drug-drug interactions: toxicological perspectives / Sidney D. Nelson --
Drug-drug interactions: marketing perspectives / Kevin J. Petty and Jose M. Vega.
Series Title: Drugs and the pharmaceutical sciences, v. 179.
Responsibility: edited by A. David Rodrigues.
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