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Dynamics of engineered artificial membranes and biosensors

Author: William Hoiles; V Krishnamurthy; Bruce Cornell
Publisher: Cambridge, United Kingdom ; New York, NY : Cambridge University Press, 2018. ©2018
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Learn about the state of the art in building artificial membranes and synthetic biological devices, and in constructing mathematical models for their dynamics at multiple time and spatial scales with this comprehensive book. Drawing on recent advances in bioengineering and biochemistry, it describes how to engineer tethered bilayer lipid membranes, bioelectronic interfaces, high-resolution biosensors, and diagnostic  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: William Hoiles; V Krishnamurthy; Bruce Cornell
ISBN: 9781108526227 1108526225
OCLC Number: 1034611071
Description: 1 online resource (xix, 453 pages)
Contents: Part I. Background: 1. Motivation and outline; 2. Biochemistry for engineers: a short primer; 3. Engineered artificial membranes; Part II. Building Engineered Membranes, Devices and Experimental Results: 4. Formation of engineered tethered membranes; 5. Ion-channel switch biosensor; 6. Physiochemical membrane platforms; 7. Experimental measurement methods for engineered membranes; Part III. Dynamic Models for Artificial Membranes: Atoms-to-Device: 8. Reaction-rate constrained models for engineered membranes; 9. Reaction-rate constrained models for the ICS biosensor; 10. Diffusion constrained continuum models of engineered membranes; 11. Electroporation models in engineered artificial membranes; 12. Electroporation measurements in engineered membranes; 13. Electrophysiological response of ion channels and cells; 14. Coarse-grained molecular dynamics; 15. All-atom molecular dynamics simulation models; 16. Closing summary for part III: from atoms to device; Appendices: Appendix A. Elementary primer on partial differential equations (PDE); Appendix B. Tutorial on coarse-grained molecular dynamics with peptides.
Responsibility: William Hoiles, Vikram Krishnamurthy, Bruce Cornell.

Abstract:

Combining synthesis with mathematical modelling, this is a state-of-the-art guide to building artificial membranes for biological devices. Supported by numerous case studies and molecular dynamics  Read more...

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