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Dynemicin A.

Author: Daniel Best
Publisher: Elsevier Science, 2016.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments.ïŽ However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis  Read more...
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Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
(OCoLC)945105382
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Daniel Best
ISBN: 0081010869 9780081010860
OCLC Number: 952666527
Description: 1 online resource (146)
Contents: 1. Dynemicin A.2. Uncialamycin.

Abstract:

Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments.ïŽ However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved.ïŽ This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs.

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