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Effects of bovine alpha-lactalbumin and casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants.
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Effects of bovine alpha-lactalbumin and casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants.

Author: WM Brück Affiliation: Food Microbial Sciences Unit, School of Food Biosciences, The University of Reading, Reading, UK.M RedgraveKM TuohyB LönnerdalG GraverholtAll authors
Edition/Format: Article Article : English
Publication:Journal of pediatric gastroenterology and nutrition, 2006 Nov; 43(5): 673-9
Database:From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Other Databases: ArticleFirstBritish Library Serials
Summary:
OBJECTIVE: Certain milk factors may promote the growth of a host-friendly gastrointestinal microbiota, for example, one that is predominated by bifidobacteria, a perceived health-promoting genus. This may explain why breast-fed infants experience fewer intestinal infections than their formula-fed counterparts who are believed to have a more diverse microbiota, which is similar to that of adults. The effects of  Read more...
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Document Type: Article
All Authors / Contributors: WM Brück Affiliation: Food Microbial Sciences Unit, School of Food Biosciences, The University of Reading, Reading, UK.; M Redgrave; KM Tuohy; B Lönnerdal; G Graverholt; O Hernell; GR Gibson
ISSN:0277-2116
Language Note: English
Unique Identifier: 110224811
Awards:

Abstract:

OBJECTIVE: Certain milk factors may promote the growth of a host-friendly gastrointestinal microbiota, for example, one that is predominated by bifidobacteria, a perceived health-promoting genus. This may explain why breast-fed infants experience fewer intestinal infections than their formula-fed counterparts who are believed to have a more diverse microbiota, which is similar to that of adults. The effects of formulas supplemented with 2 such ingredients from bovine milk, alpha-lactalbumin (alpha-lac) and casein glycomacropeptide (GMP), on gut flora were investigated in this study. PATIENTS AND METHODS: Six-week-old (4-8 wk), healthy term infants were randomised to a standard infant formula or 1 of 2 test formulae enriched in alpha-lac with higher or lower GMP until 6 months. Faecal bacteriology was determined by the culture-independent procedure fluorescence in situ hybridisation. RESULTS: There was a large fluctuation of bacterial counts within groups with no statistically significant differences between groups. Although all groups showed a predominance of bifidobacteria, breast-fed infants had a small temporary increase in counts. Other bacterial levels varied in formula-fed groups, which overall showed an adult-like faecal microflora. CONCLUSIONS: It can be speculated that a prebiotic effect for alpha-lac and GMP is achieved only with low starting populations of beneficial microbiota (eg, infants not initially breast-fed.

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