skip to content
EGFR signaling networks in cancer therapy Preview this item
ClosePreview this item
Checking...

EGFR signaling networks in cancer therapy

Author: John D Haley; William John Gullick
Publisher: New York : Humana Press, ©2008.
Series: Cancer drug discovery and development.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

The epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues. This volume probes and explores this  Read more...

Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: John D Haley; William John Gullick
ISBN: 9781588299482 1588299481 9781597453561 1597453560
OCLC Number: 293326620
Description: xi, 393 pages : illustrations ; 26 cm.
Contents: Preface Scope and aims of the volumeEGF receptor signaling: issues and challenges (W. Gullick, J. Haley)Section I: EGFR Signaling NetworksChapter 1: EGF receptor family extracellular domain structures and functions (Antony Burgess, Thomas Garrett)Chapter 2: EGF receptor heterodimerization and activation (Howard Stern)Chapter 3: Structure-function of EGFR kinase domain and inhibitors (Charles Eigenbrot)Chapter 4: Internalization and degradation of EGF receptor (Alexander Sorkin)Chapter 5: Differential dependence of EGFR and ErbB2 on the molecular chaperone Hsp90 (Wanping Xu, Len Neckers)Chapter 6: Activation of STATs 3 and 5 through the EGFR Signaling Axisa (Priya Koppikar, Jennifer Rubin Grandis)Chapter 7: The intersection of EGFR and Ras signaling pathways (Marie Wislez, Jon Kurie)Chapter 8: Phosphoinositide 3-kinase enzymes as downstream targets of the EGF receptor (Jan Domin)Chapter 9: Convergence of EGF Receptor and Src Family Signaling Networks in Cancer(Jessica E. Pritchard, Allison B. Jablonski, Sarah J. Parsons)Chapter 10: Molecular Crosstalk between E-cadherin and EGFR Signaling Networks (Julie Gavard, J. Silvio Gutkind)Chapter 11: Crosstalk between insulin-like growth factor (IGF) and epidermal growth factor (EGF) receptors (Marc Becker, Douglas Yee)Chapter 12: Negative regulation of signaling by the EGFR family (Kermit L. Carraway III, Lily Yen, Ellen Ingalla, Colleen Sweeney)Chapter 13: Nuclear ErbB receptors: Pathways and functions (Hong-Jun Liao, Graham Carpenter) Chapter 14: Temporal dynamics of EGF receptor signaling by quantitative proteomics (Blagoy Blagoev, Irina Kratchmarova, Jesper V. Olsen, Mathias Mann)Chapter 15: Computational and Mathematical Modeling of the EGFR SignalingSystem (Colin Johnson, Emmet McIntyre, William Gullick)Section II: EGFR in Tumorigenesis and EGFR Tyrosine KinaseInhibitors in Cancer TherapyChapter 16: Expression and prognostic significance of EGFR in solid tumors (Nicola Normanno, Caterina Bianco, Antonella De Luca, Luigi Strizzi, Marianna Gallo, Mario Mancino, David S. Salomon)Chapter 17: Signalling by EGF receptor in human cancers: Accentuate the positive, eliminate the negative (Haley L. Bennett, Tilman Brummer, Paul Timpson, Kate I. Patterson, Roger J. Daly)Chapter 18: EGFR in invasion, metastasis and angiogenesis (Carol Box, Joanna Peak, Susanne Rogers and Suzanne Eccles)Chapter 19: Constitutive activation of truncated EGF receptors in glioblastoma (Carol J. Wikstrand, Darell D. Bigner)Chapter 20: EGFR Mutations, Other Molecular Alterations Related To Sensitivity to EGFR Inhibitors, and Molecular Testing for EGFR-Targeted Therapies in Non-Small Cell Lung Cancer (David A. Eberhard)Chapter 21: Crosstalk Between COX-2 and EGFR: A Potential Therapeutic Opportunity (Andrew Dannenberg, Kotha Subbaramaiah)Chapter 22: Cellular sensitivity to EGF receptor inhibitors (Stuart Thomson, John D. Haley, Robert Yauch)Chapter 23: Utilizing combinations of molecular targeted agents to sensitize tumor cells to EGFR inhibitors (Elizabeth Buck, Alexandra Eyzaguirre, Kenneth K. Iwata)
Series Title: Cancer drug discovery and development.
Responsibility: edited by John D. Haley, William John Gullick.
More information:

Reviews

Editorial reviews

Publisher Synopsis

From the reviews:"This book describes the state of EGFR antagonist development and treatment modalities.... This will be of interest to those in academic research studying EGFR signaling and/or Read more...

 
User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/293326620> # EGFR signaling networks in cancer therapy
    a schema:Book, schema:CreativeWork ;
   library:oclcnum "293326620" ;
   library:placeOfPublication <http://id.loc.gov/vocabulary/countries/nyu> ;
   library:placeOfPublication <http://dbpedia.org/resource/New_York_City> ; # New York
   schema:about <http://id.loc.gov/authorities/subjects/sh85019497> ; # Cancer--Chemotherapy
   schema:about <http://id.loc.gov/authorities/subjects/sh85019547> ; # Cancer--Treatment
   schema:about <http://experiment.worldcat.org/entity/work/data/905817939#Topic/neoplasms_drug_therapy> ; # Neoplasms--drug therapy
   schema:about <http://experiment.worldcat.org/entity/work/data/905817939#Topic/neoplasms_metabolism> ; # Neoplasms--metabolism
   schema:about <http://id.worldcat.org/fast/845538> ; # Cancer--Treatment
   schema:about <http://dewey.info/class/616.99406/e22/> ;
   schema:about <http://experiment.worldcat.org/entity/work/data/905817939#Topic/signal_transduction_drug_effects> ; # Signal Transduction--drug effects
   schema:about <http://experiment.worldcat.org/entity/work/data/905817939#Topic/epidermaler_wachstumsfaktor_rezeptor> ; # Epidermaler Wachstumsfaktor-Rezeptor
   schema:about <http://id.worldcat.org/fast/845327> ; # Cancer--Chemotherapy
   schema:about <http://experiment.worldcat.org/entity/work/data/905817939#Topic/krebs_medizin> ; # Krebs (Medizin)
   schema:about <http://experiment.worldcat.org/entity/work/data/905817939#Topic/receptor_epidermal_growth_factor_antagonists_&_inhibitors> ; # Receptor, Epidermal Growth Factor--antagonists & inhibitors
   schema:about <http://experiment.worldcat.org/entity/work/data/905817939#Topic/receptor_epidermal_growth_factor_metabolism> ; # Receptor, Epidermal Growth Factor--metabolism
   schema:bookFormat bgn:PrintBook ;
   schema:contributor <http://viaf.org/viaf/161958820> ; # William John Gullick
   schema:contributor <http://viaf.org/viaf/167288506> ; # John D. Haley
   schema:copyrightYear "2008" ;
   schema:datePublished "2008" ;
   schema:exampleOfWork <http://worldcat.org/entity/work/id/905817939> ;
   schema:inLanguage "en" ;
   schema:isPartOf <http://experiment.worldcat.org/entity/work/data/905817939#Series/cancer_drug_discovery_and_development> ; # Cancer drug discovery and development.
   schema:name "EGFR signaling networks in cancer therapy"@en ;
   schema:productID "293326620" ;
   schema:publication <http://www.worldcat.org/title/-/oclc/293326620#PublicationEvent/new_york_humana_press_2008> ;
   schema:publisher <http://experiment.worldcat.org/entity/work/data/905817939#Agent/humana_press> ; # Humana Press
   schema:url <http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=017315501&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA> ;
   schema:url <http://catdir.loc.gov/catdir/enhancements/fy0906/2008923173-t.html> ;
   schema:workExample <http://worldcat.org/isbn/9781588299482> ;
   schema:workExample <http://worldcat.org/isbn/9781597453561> ;
   wdrs:describedby <http://www.worldcat.org/title/-/oclc/293326620> ;
    .


Related Entities

<http://dbpedia.org/resource/New_York_City> # New York
    a schema:Place ;
   schema:name "New York" ;
    .

<http://experiment.worldcat.org/entity/work/data/905817939#Series/cancer_drug_discovery_and_development> # Cancer drug discovery and development.
    a bgn:PublicationSeries ;
   schema:hasPart <http://www.worldcat.org/oclc/293326620> ; # EGFR signaling networks in cancer therapy
   schema:name "Cancer drug discovery and development." ;
   schema:name "Cancer drug discovery and development" ;
    .

<http://experiment.worldcat.org/entity/work/data/905817939#Topic/epidermaler_wachstumsfaktor_rezeptor> # Epidermaler Wachstumsfaktor-Rezeptor
    a schema:Intangible ;
   schema:name "Epidermaler Wachstumsfaktor-Rezeptor"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/905817939#Topic/neoplasms_drug_therapy> # Neoplasms--drug therapy
    a schema:Intangible ;
   schema:name "Neoplasms--drug therapy"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/905817939#Topic/neoplasms_metabolism> # Neoplasms--metabolism
    a schema:Intangible ;
   schema:name "Neoplasms--metabolism"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/905817939#Topic/receptor_epidermal_growth_factor_antagonists_&_inhibitors> # Receptor, Epidermal Growth Factor--antagonists & inhibitors
    a schema:Intangible ;
   schema:name "Receptor, Epidermal Growth Factor--antagonists & inhibitors"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/905817939#Topic/receptor_epidermal_growth_factor_metabolism> # Receptor, Epidermal Growth Factor--metabolism
    a schema:Intangible ;
   schema:name "Receptor, Epidermal Growth Factor--metabolism"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/905817939#Topic/signal_transduction_drug_effects> # Signal Transduction--drug effects
    a schema:Intangible ;
   schema:name "Signal Transduction--drug effects"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh85019497> # Cancer--Chemotherapy
    a schema:Intangible ;
   schema:name "Cancer--Chemotherapy"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh85019547> # Cancer--Treatment
    a schema:Intangible ;
   schema:name "Cancer--Treatment"@en ;
    .

<http://id.worldcat.org/fast/845327> # Cancer--Chemotherapy
    a schema:Intangible ;
   schema:name "Cancer--Chemotherapy"@en ;
    .

<http://id.worldcat.org/fast/845538> # Cancer--Treatment
    a schema:Intangible ;
   schema:name "Cancer--Treatment"@en ;
    .

<http://viaf.org/viaf/161958820> # William John Gullick
    a schema:Person ;
   schema:familyName "Gullick" ;
   schema:givenName "William John" ;
   schema:name "William John Gullick" ;
    .

<http://viaf.org/viaf/167288506> # John D. Haley
    a schema:Person ;
   schema:familyName "Haley" ;
   schema:givenName "John D." ;
   schema:name "John D. Haley" ;
    .

<http://worldcat.org/isbn/9781588299482>
    a schema:ProductModel ;
   schema:isbn "1588299481" ;
   schema:isbn "9781588299482" ;
    .

<http://worldcat.org/isbn/9781597453561>
    a schema:ProductModel ;
   schema:isbn "1597453560" ;
   schema:isbn "9781597453561" ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.