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Electron-gated ion channels : with amplification by NH₃ inversion resonance

Author: Wilson P Ralston
Publisher: Raleigh, NC : SciTech Pub., ©2005.
Edition/Format:   Print book : EnglishView all editions and formats
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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Wilson P Ralston
ISBN: 1891121413 9781891121418
OCLC Number: 57414466
Description: xiv, 190 pages : illustrations ; 24 cm
Contents: Machine derived contents note: Contents --
Preface xi --
Part I Theory / Electron-Gated Ion Channels --
1 Introduction 1 --
1-1. The electron-gating model 2 --
1-2. Electron gating of a sodium channel 5 --
1-3. Timing 5 --
1-4. Sodium channel current 7 --
1-5. Sensitivity 8 --
1-6. Amplification and negative conductance 8 --
1-7. Model parameters 10 --
2 Developing A Model 13 --
2-1. A single electron two-site model 13 --
2-2. Amplification 15 --
2-3. A small force constant 18 --
2-4. Calculating frequencies 19 --
2-5. Amplification by NH3 inversion resonance 21 --
2-6. A voltage dependent amplification factor 26 --
2-7. The amplification energy window 30 --
2-8. NH3 inversion frequency reduction 34 --
3 The Setcap Model 37 --
3-1. A circuit model for two-site electron tunneling 37 --
3-2. Defining a capacitance factor 40 --
3-3. Displacement capacitance 40 --
3-4. Time-constant capacitance?????? 41 --
3-5. Displacement energy 42 --
3-6. Energy well depth 45 --
3-7. The SETCAP model for N tunneling sites 47 --
4 Amplified Electron Tunneling And The Inverted Region 51 --
4-1. Amplification and the Marcus inverted region 51 --
4-2. The Q10 temperature factor 57 --
4-3. Time constant 60 --
4-4. Contact resistance 61 --
4-5. Tunneling resistance 61 --
4-6. Electron tunneling site-selectivity 62 --
4-7. The amplification energy window and the inverted region 62 --
5 Gating And Distortion Factors 64 --
5-1. Sodium channel inactivation gate leakage 65 --
5-2. Ion channel gating 69 --
5-3. Inactivation gating and open-gate distortion 72 --
5-4. Sodium channel activation gates and distortion 75 --
5-5. Potassium channel gating and distortion 77 --
5-6. Edge distortion of inactivation gating 81 --
5-7. Multistate gating 83 --
6 Characterization And Validation 85 --
6-1. Electron gating model equations 85 --
6-2. Finite-range rate constants 90 --
6-3. Open-channel probability range and time constant 95 --
6-4. Rate curves using voltage-sensitive amplification 96 --
7 Flux Gating In Sodium And Potassium Channels 99 --
7-1. Sodium channel flux gating 99 --
7-2. Sodium channel inactivation flux gating 100 --
7-3. Potassium channel flux gating 103 --
7-4. The influx gating latch-up effect 107 --
8 Far Sites, Near Sites And Back Sites 111 --
8-1. Ion channel mapping 111 --
8-2. Far sites for inactivation, calcium signaling and memory 116 --
8-3. Near sites on the S4 117 --
8-4. Back sites and hyperpolarization 117 --
8-5. Gating current 119 --
8-6. Charge immobilization 122 --
8-7. A calcium channel oscillator model using far sites 123 --
9 Electron-Gated K+ Channels 129 --
9-1. Activation and inactivation of Kv channels 130 --
9-2. Structural constraints for activation gating 133 --
9-3. Influx gating latch-up and TEA+ sensitivity 135 --
9-4. K/Na selectivity ratio 139 --
9-5. C-type inactivation gating 141 --
9-6. Coupling between tunnel-track electrons 142 --
9-7. Kinetics and inactivation depend on far sites 144 --
Part Ii Experimental / Microwave Investigation --
10 Microwave Thermal Fluorescence Spectroscopy 149 --
10-1. Microwave spectroscopy for caged proteins 149 --
10-2. Microwave spectra for Blue Fluorescent Protein 152 --
10-3. Matching frequencies 153 --
10-4. Estimating parameters and sensitivity 156 --
10-5. Arginine and lysine hot spots 165 --
10-6. Calcium oscillators --
microwave sensitivity 166 --
10-7. The first excited vibrational state 166 --
10-8. Mode switching at infrared frequencies 167 --
Appendix 171 --
A. Geometric calculations for an ?-helix 171 --
B. Time constant for a tunneling distance r 172 --
Final Comments 175 --
A brief review of the findings 176 --
References 180 --
Index 187.
Responsibility: Wilson P. Ralston.
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