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Endocrine disruption and human health

Author: Philippa D Darbre
Publisher: Amsterdam : Academic Press, [2015]
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the  Read more...
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Document Type: Book
All Authors / Contributors: Philippa D Darbre
ISBN: 9780128011393 0128011394
OCLC Number: 900032402
Description: xii, 377 pages : color illustrations ; 25 cm
Contents: Overview and scope: 1. What are the endocrine disrupters and where are they found? / Philippa D. Darbre --
2. How could endocrine disrupters affect human health? / Philippa D. Darbre. Mechanisms and assay systems: 3. Disrupters of estrogen action and synthesis / Philippa D. Darbre --
4. Disruptors of androgen action and synthesis / J. Thomas Sanderson --
5. Disrupters of thyroid hormone action and synthesis / Jenny Odum --
6. Disruption of other receptor systems: progesterone and glucocorticoid receptors, peroxisome preliferator-activated receptors, pregnane X receptor, and aryl hydrocarbon receptor / Philippa D. Darbre --
7. Nonmonotonic responses in endocrine disruption / Laura N. Vendenburg. Concerns for human health: 8. Endocrine disruption and female reproductive health / Philippa D. Darbre --
9. Endocrine disruption and male reproductive health / Philippa D. Darbre --
10. Endocrine disruption and cancer of reproductive tissues / Philippa D. Darbre, Graeme Williams --
11. Endocrine disruption of thyroid function: chemicals, mechanisms and toxicopathology / Catherine Sutcliffe, Philip W. Harvey --
12. Endocrine disruption of adrenocortical function / Philip W. Harvey --
13. Endocrine disruption of developmental pathways and children's health / Monica K. Silver, John D. Meeker --
14. Effects of endocrine disrupters on immune function and inflammation / Rodney R. Dietert --
15. Endocrine disruption and disorders of energy metabolism / Philippa D. Darbre. Public policy and regulatory considerations: 16. An introduction to the challenges for risk assessment of endocrine disrupting chemicals / Philippa D. Darbre --
17. Regulatory considerations for endocrine disrupters in food / Gerard M. Cooke, Rekha Mehta --
18. Considerations of endocrine disrupters in drinking water / Rowena H. Gee, Leon S. Rockett, Paul C. Rumsby --
19. Regulatory considerations for dermal application of endocrine disrupters in personal care products / Philippa D. Darbre, Philip W. Harvey.
Responsibility: edited by Philippa D. Darbre.
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Abstract:

Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human healthPresents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human healthOffers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations.

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"...a comprehensive resource for toxicology students and practitioners...the first book that specifically focuses in detail on endocrine disruption and its related human health issues. Score: 96 - 4 Read more...

 
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