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Environmental Chemicals, Enzyme Function and Human Disease.

Author: CIBA Foundation Symposium
Publisher: Hoboken : John Wiley & Sons, 2009.
Series: Novartis Foundation Symposia.
Edition/Format:   eBook : Document : English
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Genre/Form: Electronic books
Conference papers and proceedings
Congresses
Additional Physical Format: Print version:
Symposium, CIBA Foundation.
Environmental Chemicals, Enzyme Function and Human Disease.
Hoboken : John Wiley & Sons, ©2009
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: CIBA Foundation Symposium
ISBN: 9780470718278 0470718277
OCLC Number: 797918460
Description: 1 online resource (392 pages).
Contents: Environmental Chemicals Enzyme Function and Human Disease; Contents; Chairman's introduction; The role of the drug-metabolizing enzymes; Discussion; The influence of inducers on drug-metabolizing enzyme activity and on formation of reactive drug metabolites in the liver; Discussion; Effects of inducers and inhibitors on drug-metabolizing enzymes and on drug toxicity in extrahepatic tissues; Discussion; Induction of enzymes involved in DNA repair and mutagenesis; Discussion. Induction of drug-metabolizing enzymes by polycyclic aromatic hydrocarbons: mechanisms, and some implications in environmental health researchDiscussion; Discussion; Induction of drug-metabolizing enzymes by phenobarbitone: structural and biochemical aspects; Substrate-dependent irreversible inactivation of cytochrome P-450: conversion of its haem moiety into modified porphyrins; Discussion; General Discussion I; Regulation of human drug metabolism by dietary factors; Discussion; Influence of foreign compounds on formation and disposition of reactive metabolites; Discussion. Pharmacokinetic factors governing the steady-state concentrations of foreign chemicals and their metabolitesDiscussion; Toxicological implications of polymorphic drug metabolism; Immunologically mediated toxicity; Discussion; Toxicological significance of liver hypertrophy produced by inducers of drug-metabolizing enzymes; Discussion; Discussion; Discussion; The influence of nutrition and inducers on mechanisms of toxicity in humans and animals; Influence of environmental chemicals on drug therapy in humans: studies with contraceptivesteroids; Discussion; General Discussion II. Vitamin D metabolism in patients treated with phenytoin and phenobarbitoneDiscussion; Chemical disease in humans: problems in comparative toxicology; Discussion; Implications for future studies in humans; Final General Discussion; Index of Contributors; Subject Index.
Series Title: Novartis Foundation Symposia.

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