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Enzyme inhibition in drug discovery and development : the good and the bad

Autor: Chuang Lu; A P Li
Editorial: Hoboken, N.J. : Wiley, ©2010.
Edición/Formato:   Libro : Inglés (eng)Ver todas las ediciones y todos los formatos
Base de datos:WorldCat
Resumen:
"Offering a unique approach that includes both the pharmacologic and pharmacokinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development." "Through this focused, single-source reference on the fundamentals of drug discovery and development,  Leer más
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Tipo de material: Recurso en Internet
Tipo de documento: Libro/Texto, Recurso en Internet
Todos autores / colaboradores: Chuang Lu; A P Li
ISBN: 9780470281741 047028174X
Número OCLC: 318292649
Descripción: xiii, 854 p., [8] p. of plates : ill. (some col.) ; 25 cm.
Contenido: The drug discovery process / Gerald T. Miwa --
Medicinal chemistry of the optimization of enzyme inhibitors / Geraldine Harriman, Amy Elder, and Indranath Ghosh --
Bioanalytical technologies in drug discovery / Jing-Tao Wu --
Safety biomarkers in drug development : emerging trends and implications / Eric R. Fedyk --
The role of drug metabolism in drug discovery / Tonika Bohnert and Liang-Shang Gan --
Applied pharmacokinetics in drug discovery and development / Hua Yang ... [et al.] --
Enzyme inhibition and inactivation : cytochrome P450 enzymes / R. Scott Obach --
Cytochrome P450 induction / Edward L. LeCluyse ... [et al.] --
Inhibition of drug-metabolizing enzymes in gastrointestinal tract and its influence on the drug-drug interaction prediction / Aleksandra Galetin and J. Brian Houston --
Enzyme inhibition in various in vitro systems / Ping Zhao --
Cytochrome P450 degradation and its clinical relevance / Mingxiang Liao ... [et al.] --
Complexities of working with UDP-glucuronosyltransferases (UGTs) : focus on enzyme inhibition / Michael B. Fisher --
Evaluation of inhibitors of drug metabolism in human hepatocytes / Albert P. Li and Chuang Lu --
Grapefruit juice and its constituents as new esterase inhibitors / Suresh K. Balani --
Transporter-xenobiotic interactions : an important aspect of drug development studies / Gang Luo, Richard Ridgewell, and Thomas Guenthner --
Polymorphisms of drug transporters and their clinical implications / Cindy Q. Xia and Johnny J. Yang --
Clinical drug interactions due to metabolic inhibition : prediction, assessment, and interpretation / Lisa L. von Moltke and David J. Greenblatt --
Predicting interindividual variability of metabolic drug-drug interactions : identifying the causes and accounting for them using a systems approach / Amin Rostami-Hodjegan --
NF-kB : mechanism, tumor biology, and inhibitors / Lenny Dang --
G-protein-coupled receptors as drug targets / Wenyan Miao and Lijun Wu --
Pharmacological modulation of ion channels for the treatment of chronic pain / Yi Liu and Ning Qin --
Targeting the mTOR pathway for tumor therapeutics / Wei Chen --
HIV-1 protease inhibitors as antiretroviral agents / Sergei V. Gulnik, Elena Afonina, and Michael Eissenstat.
Responsabilidad: edited by Chuang Lu, Albert P. Li.

Resumen:

This book covers the science and approaches of enzyme inhibition applied in drug discovery and drug development, including both pharmacology and pharmacokinetic aspects of enzyme inhibition.  Leer más

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"The description of each topic is clear, well organized and informative, making the book a useful or even essential high-level handbook." (ChemMedChem, November 2010)

 
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schema:reviewBody""Offering a unique approach that includes both the pharmacologic and pharmacokinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development." "Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medical chemists will also broaden their understanding of DMPK."--BOOK JACKET."
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