aller au contenu
Enzyme inhibition in drug discovery and development : the good and the bad Aperçu de cet ouvrage
FermerAperçu de cet ouvrage
Vérifiant…

Enzyme inhibition in drug discovery and development : the good and the bad

Auteur : Chuang Lu; A P Li
Éditeur : Hoboken, N.J. : Wiley, ©2010.
Édition/format :   Livre : AnglaisVoir toutes les éditions et tous les formats
Base de données :WorldCat
Résumé :
"Offering a unique approach that includes both the pharmacologic and pharmacokinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development." "Through this focused, single-source reference on the fundamentals of drug discovery and development,  Lire la suite...
Évaluation :

(pas encore évalué) 0 avec des critiques - Soyez le premier.

Sujets
Plus comme ceci

 

Trouver un exemplaire en ligne

Liens vers cet ouvrage

Trouver un exemplaire dans la bibliothèque

&AllPage.SpinnerRetrieving; Recherche de bibliothèques qui possèdent cet ouvrage...

Détails

Type d’ouvrage : Ressource Internet
Format : Livre, Ressource Internet
Tous les auteurs / collaborateurs : Chuang Lu; A P Li
ISBN : 9780470281741 047028174X
Numéro OCLC : 318292649
Description : xiii, 854 pages, [8] pages of plates : illustrations (some color) ; 25 cm
Contenu : The drug discovery process / Gerald T. Miwa --
Medicinal chemistry of the optimization of enzyme inhibitors / Geraldine Harriman, Amy Elder, and Indranath Ghosh --
Bioanalytical technologies in drug discovery / Jing-Tao Wu --
Safety biomarkers in drug development : emerging trends and implications / Eric R. Fedyk --
The role of drug metabolism in drug discovery / Tonika Bohnert and Liang-Shang Gan --
Applied pharmacokinetics in drug discovery and development / Hua Yang [and others] --
Enzyme inhibition and inactivation : cytochrome P450 enzymes / R. Scott Obach --
Cytochrome P450 induction / Edward L. LeCluyse [and others] --
Inhibition of drug-metabolizing enzymes in gastrointestinal tract and its influence on the drug-drug interaction prediction / Aleksandra Galetin and J. Brian Houston --
Enzyme inhibition in various in vitro systems / Ping Zhao --
Cytochrome P450 degradation and its clinical relevance / Mingxiang Liao [and others] --
Complexities of working with UDP-glucuronosyltransferases (UGTs) : focus on enzyme inhibition / Michael B. Fisher. Evaluation of inhibitors of drug metabolism in human hepatocytes / Albert P. Li and Chuang Lu --
Grapefruit juice and its constituents as new esterase inhibitors / Suresh K. Balani --
Transporter-xenobiotic interactions : an important aspect of drug development studies / Gang Luo, Richard Ridgewell, and Thomas Guenthner --
Polymorphisms of drug transporters and their clinical implications / Cindy Q. Xia and Johnny J. Yang --
Clinical drug interactions due to metabolic inhibition : prediction, assessment, and interpretation / Lisa L. von Moltke and David J. Greenblatt --
Predicting interindividual variability of metabolic drug-drug interactions : identifying the causes and accounting for them using a systems approach / Amin Rostami-Hodjegan --
NF-kB : mechanism, tumor biology, and inhibitors / Lenny Dang --
G-protein-coupled receptors as drug targets / Wenyan Miao and Lijun Wu --
Pharmacological modulation of ion channels for the treatment of chronic pain / Yi Liu and Ning Qin --
Targeting the mTOR pathway for tumor therapeutics / Wei Chen --
HIV-1 protease inhibitors as antiretroviral agents / Sergei V. Gulnik, Elena Afonina, and Michael Eissenstat.
Responsabilité : edited by Chuang Lu, Albert P. Li.

Résumé :

This book covers the science and approaches of enzyme inhibition applied in drug discovery and drug development, including both pharmacology and pharmacokinetic aspects of enzyme inhibition.  Lire la suite...

Critiques

Critiques éditoriales

Synopsis de l’éditeur

"The description of each topic is clear, well organized and informative, making the book a useful or even essential high-level handbook." (ChemMedChem, November 2010)

 
Critiques d’utilisateurs
Récupération des critiques de GoodReads...
Récuperation des critiques DOGObooks…

Tags

Tous les tags des utilisateurs (1)

Voir les tags les plus utilisés sous forme de : liste de tags | nuage de tags

Ouvrages semblables

Sujets associés :(6)

Listes d’utilisateurs dans lesquelles cet ouvrage apparaît (1)

Confirmez cette demande

Vous avez peut-être déjà demandé cet ouvrage. Veuillez sélectionner OK si vous voulez poursuivre avec cette demande quand même.

Données liées


<http://www.worldcat.org/oclc/318292649>
library:oclcnum"318292649"
library:placeOfPublication
library:placeOfPublication
rdf:typeschema:MediaObject
rdf:typeschema:Book
schema:about
schema:about
schema:about
schema:about
schema:about
schema:about
schema:about
schema:about
schema:contributor
schema:contributor
schema:copyrightYear"2010"
schema:datePublished"2010"
schema:description"The drug discovery process / Gerald T. Miwa -- Medicinal chemistry of the optimization of enzyme inhibitors / Geraldine Harriman, Amy Elder, and Indranath Ghosh -- Bioanalytical technologies in drug discovery / Jing-Tao Wu -- Safety biomarkers in drug development : emerging trends and implications / Eric R. Fedyk -- The role of drug metabolism in drug discovery / Tonika Bohnert and Liang-Shang Gan -- Applied pharmacokinetics in drug discovery and development / Hua Yang [and others] -- Enzyme inhibition and inactivation : cytochrome P450 enzymes / R. Scott Obach -- Cytochrome P450 induction / Edward L. LeCluyse [and others] -- Inhibition of drug-metabolizing enzymes in gastrointestinal tract and its influence on the drug-drug interaction prediction / Aleksandra Galetin and J. Brian Houston -- Enzyme inhibition in various in vitro systems / Ping Zhao -- Cytochrome P450 degradation and its clinical relevance / Mingxiang Liao [and others] -- Complexities of working with UDP-glucuronosyltransferases (UGTs) : focus on enzyme inhibition / Michael B. Fisher."@en
schema:description"Evaluation of inhibitors of drug metabolism in human hepatocytes / Albert P. Li and Chuang Lu -- Grapefruit juice and its constituents as new esterase inhibitors / Suresh K. Balani -- Transporter-xenobiotic interactions : an important aspect of drug development studies / Gang Luo, Richard Ridgewell, and Thomas Guenthner -- Polymorphisms of drug transporters and their clinical implications / Cindy Q. Xia and Johnny J. Yang -- Clinical drug interactions due to metabolic inhibition : prediction, assessment, and interpretation / Lisa L. von Moltke and David J. Greenblatt -- Predicting interindividual variability of metabolic drug-drug interactions : identifying the causes and accounting for them using a systems approach / Amin Rostami-Hodjegan -- NF-kB : mechanism, tumor biology, and inhibitors / Lenny Dang -- G-protein-coupled receptors as drug targets / Wenyan Miao and Lijun Wu -- Pharmacological modulation of ion channels for the treatment of chronic pain / Yi Liu and Ning Qin -- Targeting the mTOR pathway for tumor therapeutics / Wei Chen -- HIV-1 protease inhibitors as antiretroviral agents / Sergei V. Gulnik, Elena Afonina, and Michael Eissenstat."@en
schema:exampleOfWork<http://worldcat.org/entity/work/id/795011628>
schema:inLanguage"en"
schema:name"Enzyme inhibition in drug discovery and development : the good and the bad"@en
schema:publication
schema:publisher
schema:reviews
rdf:typeschema:Review
schema:itemReviewed<http://www.worldcat.org/oclc/318292649>
schema:reviewBody""Offering a unique approach that includes both the pharmacologic and pharmacokinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development." "Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medical chemists will also broaden their understanding of DMPK."--Jacket."
schema:workExample
wdrs:describedby

Content-negotiable representations

Fermer la fenêtre

Veuillez vous identifier dans WorldCat 

Vous n’avez pas de compte? Vous pouvez facilement créer un compte gratuit.