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|Additional Physical Format:||Online version:
Enzymes in synthetic organic chemistry.
Oxford, U.K.: Pergamon ; Tarrytown N.Y. : Elsevier Science, 1994
|All Authors / Contributors:||
Chi-Huey Wong; G M Whitesides
|ISBN:||0080359426 9780080359427 0080359418 9780080359410|
|Description:||xvii, 370 pages : illustrations ; 26 cm.|
|Contents:||Ch. 1. General Aspects. 1. Rate Acceleration in Enzyme-Catalyzed Reactions. 2. Michaelis-Menten Kinetics. 3. Enzyme Inhibition. 4. Specificity. 5. Improvement or Alteration of Enzyme Specificity. 6. Enzyme Stabilization and Reactor Configuration. 7. Cofactor Regeneration. 8. Enzyme Catalysis in Organic Solvents. 9. Multienzyme Systems and Metabolic Engineering. 10. Rational Design of New Enzymatic Catalysts --
Ch. 2. Use of Hydrolytic Enzymes: Amidases, Proteases, Esterases, Lipases, Nitrilases, Phosphatases, Epoxide Hydrolases. 1. Amidases. 2. Protease-Catalyzed Peptide Synthesis. 3. Proteases that Act as Esterases. 4. Acetylcholine Esterase. 5. Pig Liver Esterase. 6. Phospholipases. 7. Cholesterol Esterase. 8. Lipases. 9. Nitrile Hydrolysis Enzymes. 10. Epoxide Hydrolase. 11. Phosphatase --
Ch. 3. Oxidoreductions. 1. Nicotinamide Cofactor Dependent Oxidoreductions. 2. Dehydrogenases which Utilize Ketoacids as Substrates. 3. Other NAD(P)-Dependent Dehydrogenases. 4. Oxidoreductases that are Metalloenzymes --
Ch. 4. C-C Bond Formation. 1. Aldol Condensation. 2. Ketol and Aldol Transfer Reactions. 3. Addition of HCN to Aldehydes. 4. Acyloin Condensation. 5. C-C Bond Forming Reactions Involving AcetylCoA. 6. Isoprenoid and Steroid Synthesis. 7. [beta]-Replacement of Chloroalanine. 8. C-C Bond Formation Catalyzed by Vitamin B[subscript 12] --
Ch. 5. Synthesis of Glycoside Bonds. 1. Background. 2. Glycosyltransferases of the Leloir Pathway. 3. Non-Leloir Glycosyltransferases: Transfer of Glycosyl Donors from Glycosyl Phosphates and Glycosides. 4. Glycosidases. 5. Transglycosidases. 6. Synthesis of N-Glycosides. 7. Biological Applications of Synthetic Glycoconjugates. 8. Future Opportunities --
Ch. 6. Addition, Elimination and other Group Transfer Reactions (Phosphoryl-, Methyl-, Sulfo- and Amino-Transfer Reactions). 1. Addition of Water to Alkenes: Fumarase. 2. Addition of Ammonia to Double Bonds: Ammonia Lyases. 3. Transamination: Aminotransferases. 4. Addition and Elimination of the Carboxyl Group. 5. Nucleoside Triphosphate Requiring Enzymatic Reactions. 6. Preparation of Derivatives of ATP Chiral at the [alpha]-, [beta]- or [gamma]-Phosphorus. 7. Phosphorothioate-Containing DNA and RNA (DNA-S and RNA-S). 8. DNA and RNA Oligomers. 9. Incorporation of Modified or Unnatural Bases into DNA or RNA. 10. Dehalogenation. 11. Synthesis of Chiral Methyl Groups. 12. S-Adenosylmethionine and Transmethylation. 13. Sulfate Activation and Transfer Reactions.
|Series Title:||Tetrahedron organic chemistry series, v. 12.|
|Responsibility:||C.H. Wong and G.M. Whitesides.|
Stanley M. Roberts In summary this is an important text book written by two persons with outstanding reputations in the field. For a scientist working in the area it is like a good novel - having