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Essays in toxicology. Volume 4

Author: Wayland J Hayes, Jr.
Publisher: New York : Academic Press, 1973.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Essays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace elements. The first essay examines certain dependence-producing drugs; the mechanism of tolerance to barbiturates by changes in drugs metabolism; the distribution of barbiturates to the central nervous system; and the urinary excretion of  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Essays in toxicology. Vol. 4.
New York ; London : Academic Press. 1973
(OCoLC)222458353
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Wayland J Hayes, Jr.
ISBN: 9781483216447 1483216446
OCLC Number: 884496808
Description: 1 online resource : illustrations
Contents: Front Cover; Essays in Toxicology; Copyright Page; Table of Contents; List of Contribotors; Preface; Contents of Previons Volnmes; Chapter 1. Drug Dependence: Whither the Drug?; I. Introduction; II. Mechanism of Tolerance to Barbiturates by Changes in Drug Metabolism; III, Distribution of Barbiturates to the Central Nervous System; IV, Urinary Excretion of Barbiturates; V. Unmasking the Culprit-Heroin; VI. Metabolism of Morphine; VII. Metabolic Transformation of Codeine to Morphine; VIII. Metabolism of Naloxone; IX. Excretion of Narcotics and Metabolites in Urine; X. Transport in Brain. VIII. Longevity and Median Life-SpanIX. Other Manifestations of Recondite Toxicity; X. Recondite Toxicity of Trace Elements as Expressed by Effects on Reproduction of Rats and Mice; XI. Some Clues to Mechanisms of Toxicity; XII. Production of Chronic Diseases Stimulating Human Disorders; XIII. Recondite Toxicity of Other Metals or Elements in Man; XIV. Innate Toxicity from Water; XV. Summary and Conclusions; References; AUTHOR INDEX; SUBJECT INDEX.
Responsibility: edited by Wayland J. Hayes.

Abstract:

Essays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace elements. The first essay examines certain dependence-producing drugs; the mechanism of tolerance to barbiturates by changes in drugs metabolism; the distribution of barbiturates to the central nervous system; and the urinary excretion of barbiturates. The formation of morphine from heroin and codeine, and the dealkylation to form normorphine and to reduce naloxone to another compound is also considered in the first essay.

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