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Eukaryotic DNA damage surveillance and repair

Author: Keith W Caldecott
Publisher: Georgetown, Tex. : Landes Bioscience/Eurekah.com ; New York, N.Y. : Kluwer Academic/Plenum Publishers, ©2004.
Series: Molecular biology intelligence unit (Unnumbered)
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

Eukaryotic DNA Damage Surveillance and Repair contains chapters from experts in the field of DNA damage detection, repair, and cell cycle control.

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Keith W Caldecott
ISBN: 0306479877 9780306479878
OCLC Number: 53224841
Description: 161 pages : illustrations (some color) ; 24 cm.
Contents: 1. DNA Damage Surveillance in Saccharomyces cerevisiae / Geraldine W-L. Toh, Stefano Maffini, Noel F. Lowndes 1 --
Sensing DNA Damage: A Complex Problem 4 --
From Checkpoint Genes to Protein Complexes 6 --
The Rad24 Epistasis Group: RFC-Like and PCNA-Like Complexes 7 --
Mec1/Ddc2: Signal Transduction and More 10 --
The Mre11 Complex: DSBs and Checkpoint Signalling 12 --
The S Phase Checkpoint 15 --
Checkpoints and Genome Surveillance 16 --
Focal Recruitment of Checkpoint and Repair Complexes to Damage Sites 17 --
The Chromatin Connection 18 --
2. Mammalian Base Excision Repair / Grigory L. Dianov, Sarah L. Allinson, Helen Budworth, Kate Sleeth 27 --
Base Excision Repair Proteins 28 --
Coordination of Base Excision Repair 36 --
3. Detection and Repair of DNA Single-Strand Breaks / Keith W. Caldecott 49 --
The Origin and Structure of DNA Single-Strand Breaks 49 --
The Threat of Single-Strand Breaks to Genetic Stability and Cell Death 50 --
Polypeptides Involved in DNA Single-Strand Break Repair 50 --
PARP-1, XRCC1 and the Detection of SSBs 50 --
AP Endonuclease-1 (APE1) 53 --
Polynucleotide Kinase (PNK) 54 --
DNA Polymerase-[beta] (Pol[beta]) 54 --
DNA Ligase III 55 --
SSBR Protein Complexes; Pre-Formed or Assembled at Breaks? 56 --
SSBR Pathways and the Cell Cycle 57 --
4. The Detection and Repair of Nucleotide Damage and Coupling to Major Cellular Regulatory Processes in Mammalian Cells / James E. Cleaver 63 --
Types of Damage Repaired by NER 66 --
Recognition of Damage in Nontranscribing Regions of the Genome 67 --
Recognition of Damage in Transcriptionally Active Regions of the Genome 68 --
The Core Excision Process Common to GGR and TCR 70 --
Ubiquitination and Proteolysis in DNA Repair 73 --
Inducible Responses to UV Irradiation 74 --
Kinase Activation and Cellular Response to UV Damage 75 --
Replication of Damaged DNA 76 --
Differentiation and Tissue-Specific Expression of DNA Repair Genes 78 --
Polymorphisms in DNA Repair Genes 78 --
5. Mammalian DNA Mismatch Repair / Helen M.R. Robinson, Robert Brown 90 --
What Is DNA Mismatch Repair 90 --
The Mismatch Repair Mechanism 91 --
The Mismatch Repair Proteins 93 --
The MutS Homolog Proteins 96 --
Proteins That Interact with the MuL and MutS Homologues 98 --
Apoptosis and Drug Resistance 101 --
MMR and Apoptotic Pathways 102 --
6. Origin, Recognition, Signaling and Repair of DNA Double-Strand Breaks in Mammalian Cells / Larry H. Thompson, Charles L. Limoli 107 --
Replication-Independent Double-Strand Breaks (DSBs) 108 --
Replication Associated DSBs (One-Sided Breaks) 121 --
7. The Mechanism of DNA Non-Homologous End-Joining: Lessons Learned from Biophysical, Biochemical and Cellular Studies / P.A. Jeggo 146 --
Nature of the DNA Ends to Be Rejoined 147 --
Structure and Biochemical Analysis of the Core NHEJ Proteins 148 --
Additional Proteins Implicated in DNA NHEJ 150 --
Further Proteins Interacting with Core NHEJ Components 151 --
Model for NHEJ and Potential Additional Interacting Proteins 152.
Series Title: Molecular biology intelligence unit (Unnumbered)
Responsibility: [edited by] Keith W. Caldecott.
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