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The evaluation of surrogate endpoints

Author: Geert Molenberghs; Marc E Buyse; Tomasz Burzykowski
Publisher: New York : Springer, ©2005.
Series: Statistics for biology and health.
Edition/Format:   Print book : EnglishView all editions and formats
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Covers the research on a sensitive and controversial topic in a professional manner. This title provides an outlook as well as model guidelines and software tools that should be of interest to people  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Geert Molenberghs; Marc E Buyse; Tomasz Burzykowski
ISBN: 0387202773 9780387202778 1441919066 9781441919069
OCLC Number: 56807737
Description: xxiii, 408 pages : illustrations.
Contents: Introduction --
Setting the Scene --
Regulatory Aspects in Using Surrogate Markers in Clinical Trials --
Notation and Motivating Studies --
The History of Surrogate Marker Validation --
Validation Using Single-Trial Data: Mixed Binary and Continuous Outcomes --
A Meta-Analytic Validation Framework for Contiuous Outcomes --
The Choice of Units --
Extensions of the Meta-Analytic Approach to Surrogate Endpoints --
Meta-Analytic Validation with Binary Outcomes --
Validation in the Case of Two Failure-Time Endpoints --
An Ordinal Surrogate for a Survival True Endpoint --
A Combination of Longitudinal and Survival Endpoints --
Repeated Measures and Surrogate Marker Validation --
Bayesian Evaluation of Surrogate Endpoints --
Surrogate Marker Validation in Mental Health --
The Evaluation of Surrogate Endpoints in Practice: Experience in HIV --
An Alternative Measure for Meta-Analytic Surrogate Marker Validation --
Discussion: Surrogate Endpoint Definition and Evaluation --The Promise and Peril of Surrogate End Points in Cancer Research.
Series Title: Statistics for biology and health.
Responsibility: Tomasz Burzykowski, Geert Molenberghs, Marc Buyse, editors.
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From the reviews:"A strength of this book is its comprehensive and up-to-date presentation of issues pertinent to the evaluation of surrgoate endpoints...This book makes an important contribution to Read more...

 
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