skip to content
The Evolution and Development of the Antibody Repertoire. Preview this item
ClosePreview this item
Checking...

The Evolution and Development of the Antibody Repertoire.

Author: Harry W. Schroeder Jr.
Publisher: Frontiers Media SA 2015.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Although at first glance mechanisms used to create the variable domains of immunoglobulin appear to be designed to generate diversity at random, closer inspection reveals striking evolutionary constraints on the sequence and structure of these antigen receptors, suggesting that natural selection is operating to create a repertoire that anticipates or is biased towards recognition of specific antigenic properties.  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Harry W. Schroeder Jr.
ISBN: 9782889195497 288919549X
OCLC Number: 945783161
Language Note: English.
Description: 1 electronic resource (122 pages)
Other Titles: Directory of open access books.

Abstract:

Although at first glance mechanisms used to create the variable domains of immunoglobulin appear to be designed to generate diversity at random, closer inspection reveals striking evolutionary constraints on the sequence and structure of these antigen receptors, suggesting that natural selection is operating to create a repertoire that anticipates or is biased towards recognition of specific antigenic properties. This Research Topics issue will be devoted to an examination of the evolution of antigen receptor sequence at the germline level, an evaluation of the repertoire in B cells from fish, pigs and human, an introduction into bioinformatics approaches to the evaluation and analysis of the repertoire as ascertained by high throughput sequencing, and a discussion of how study of the normal repertoire informs the construction or selection of in vitro antibodies for applied purposes.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/945783161> # The Evolution and Development of the Antibody Repertoire.
    a schema:MediaObject, schema:CreativeWork, schema:Book ;
    library:oclcnum "945783161" ;
    rdfs:seeAlso <http://experiment.worldcat.org/entity/work/data/2969406168#CreativeWork/directory_of_open_access_books> ; # Directory of open access books.
    schema:about <http://experiment.worldcat.org/entity/work/data/2969406168#Topic/medicine_general> ; # Medicine (General)
    schema:about <http://experiment.worldcat.org/entity/work/data/2969406168#Thing/comparative_immunology> ; # comparative immunology
    schema:about <http://experiment.worldcat.org/entity/work/data/2969406168#Thing/sequence_analysis_software> ; # sequence analysis software
    schema:about <http://experiment.worldcat.org/entity/work/data/2969406168#Topic/immunologic_diseases_allergy> ; # Immunologic diseases. Allergy
    schema:about <http://experiment.worldcat.org/entity/work/data/2969406168#Thing/natural_antibodies> ; # natural antibodies
    schema:about <http://experiment.worldcat.org/entity/work/data/2969406168#Thing/immunoglobulin> ; # immunoglobulin
    schema:about <http://experiment.worldcat.org/entity/work/data/2969406168#Thing/b_cells> ; # B cells
    schema:about <http://experiment.worldcat.org/entity/work/data/2969406168#Thing/antibody_repertoire> ; # Antibody repertoire
    schema:author <http://experiment.worldcat.org/entity/work/data/2969406168#Person/harry_w_schroeder_jr> ; # Harry W. Schroeder Jr.
    schema:bookFormat schema:EBook ;
    schema:datePublished "2015" ;
    schema:description "Although at first glance mechanisms used to create the variable domains of immunoglobulin appear to be designed to generate diversity at random, closer inspection reveals striking evolutionary constraints on the sequence and structure of these antigen receptors, suggesting that natural selection is operating to create a repertoire that anticipates or is biased towards recognition of specific antigenic properties. This Research Topics issue will be devoted to an examination of the evolution of antigen receptor sequence at the germline level, an evaluation of the repertoire in B cells from fish, pigs and human, an introduction into bioinformatics approaches to the evaluation and analysis of the repertoire as ascertained by high throughput sequencing, and a discussion of how study of the normal repertoire informs the construction or selection of in vitro antibodies for applied purposes."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/2969406168> ;
    schema:inLanguage "en" ;
    schema:name "The Evolution and Development of the Antibody Repertoire."@en ;
    schema:productID "945783161" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/945783161#PublicationEvent/frontiers_media_sa2015> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/2969406168#Agent/frontiers_media_sa> ; # Frontiers Media SA
    schema:url <http://journal.frontiersin.org/researchtopic/369/the-evolution-and-development-of-the-antibody-repertoire> ;
    schema:url <http://www.doabooks.org/doab?func=fulltext&rid=18158> ;
    schema:workExample <http://worldcat.org/isbn/9782889195497> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/945783161> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/2969406168#Agent/frontiers_media_sa> # Frontiers Media SA
    a bgn:Agent ;
    schema:name "Frontiers Media SA" ;
    .

<http://experiment.worldcat.org/entity/work/data/2969406168#CreativeWork/directory_of_open_access_books> # Directory of open access books.
    a schema:CreativeWork ;
    schema:name "Directory of open access books." ;
    .

<http://experiment.worldcat.org/entity/work/data/2969406168#Person/harry_w_schroeder_jr> # Harry W. Schroeder Jr.
    a schema:Person ;
    schema:name "Harry W. Schroeder Jr." ;
    .

<http://experiment.worldcat.org/entity/work/data/2969406168#Thing/antibody_repertoire> # Antibody repertoire
    a schema:Thing ;
    schema:name "Antibody repertoire" ;
    .

<http://experiment.worldcat.org/entity/work/data/2969406168#Thing/comparative_immunology> # comparative immunology
    a schema:Thing ;
    schema:name "comparative immunology" ;
    .

<http://experiment.worldcat.org/entity/work/data/2969406168#Thing/immunoglobulin> # immunoglobulin
    a schema:Thing ;
    schema:name "immunoglobulin" ;
    .

<http://experiment.worldcat.org/entity/work/data/2969406168#Thing/natural_antibodies> # natural antibodies
    a schema:Thing ;
    schema:name "natural antibodies" ;
    .

<http://experiment.worldcat.org/entity/work/data/2969406168#Thing/sequence_analysis_software> # sequence analysis software
    a schema:Thing ;
    schema:name "sequence analysis software" ;
    .

<http://experiment.worldcat.org/entity/work/data/2969406168#Topic/immunologic_diseases_allergy> # Immunologic diseases. Allergy
    a schema:Intangible ;
    schema:name "Immunologic diseases. Allergy"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/2969406168#Topic/medicine_general> # Medicine (General)
    a schema:Intangible ;
    schema:name "Medicine (General)"@en ;
    .

<http://worldcat.org/isbn/9782889195497>
    a schema:ProductModel ;
    schema:isbn "288919549X" ;
    schema:isbn "9782889195497" ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.