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Evolution and Variation of Multigene Families

Author: Tomoko Ohta
Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 1980.
Series: Lecture Notes in Biomathematics, 37; Lecture notes in biomathematics, 37.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:

During the last decade and a half, studies of evolution and variation have been revolutionized by the introduction of the methods and concepts of molecular genetics.

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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Tomoko Ohta
ISBN: 9783642931383 3642931383 9783540099987 3540099980
OCLC Number: 858931518
Description: 1 online resource.
Contents: 1 Organization and Properties of Antibody Genes and Other Multigene Families --
1.1 Multigene family --
1.2 Antibody gene families --
1.3 Coincidental evolution --
2 Models of Unequal Crossing-Over --
2.1 Simulation studies of the model of unequal crossing-over --
2.2 Diffusion approximation of coincidental evolution --
2.3 Coincidental evolution as a birth-death process --
3 Population Genetics Approach --
3.1 Model --
3.2 Approximate analyses by double diffusion process --
4 Decrease of Genetic Correlation with Distance Between Gene Members on the Chromosome --
4.1 Unequal crossing-over by shift of one gene unit --
4.2 Unequal crossing-over by shift of more than one gene --
4.3 Average identity coefficient --
5 Genetic Differentiation of Multigene Families --
5.1 Identity coefficient between the populations --
5.2 Variance and covariance of identity coefficients --
5.3 Numerical examples and some applications --
6 Statistical Analyses on Sequence Variability of Immunoglobulins --
6.1 Average identity coefficient --
6.2 Identity coefficient in association with subfamilies of variable region sequences --
6.3 Variance and covariance of identity coefficients --
7 Linkage Disequilibrium Between Amino Acid Sites in a Multigene Family --
7.1 Variance of linkage disequilibrium coefficients --
7.2 Application to sequence variability of immunoglobulins --
8 Prospects for Future Research --
8.1 Gene conversion and other mechanisms to increase homogeneity --
8.2 Non-constant gene family size --
8.3 Accumulation of non-functional genes --
8.4 Natural selection on gene diversity --
8.5 Possible other examples to apply the theory --
8.6 Multigene family of small size --
8.7 Concluding remarks --
References.
Series Title: Lecture Notes in Biomathematics, 37; Lecture notes in biomathematics, 37.
Responsibility: by Tomoko Ohta.

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