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Evolution in cancer

Author: Carlo Maley; Hong Kong University of Science and Technology. Institute for Advanced Study.
Publisher: [Hong Kong : Hong Kong University of Science and Technology, 2009]
Series: IAS Workshop on evolution: foundations, fundamentals, and disease., Session 3,, The role of evolution in biological disease : cancer and cell dynamics ;, Talk no.1.
Edition/Format:   eVideo : Clipart/images/graphics : English
Database:WorldCat
Summary:
"Our current theory of carcinogenesis is that mutant clones arise through genetic or epigenetic instability, and if they have a reproductive or survival advantage over other cells in the tumor, within their microenvironment, they will expand in the tumor in a selective sweep. Thus, we believe carcinogenesis is characterized by a series of selective sweeps. However, virtually all data on that process to date is  Read more...
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Genre/Form: Streaming video
Filmed lectures
Nonfiction films
Material Type: Clipart/images/graphics, Internet resource, Videorecording
Document Type: Internet Resource, Computer File, Visual material
All Authors / Contributors: Carlo Maley; Hong Kong University of Science and Technology. Institute for Advanced Study.
OCLC Number: 665133798
Notes: Title from opening screen (viewed 30 Aug., 2010).
The Workshop on Evolution: Foundations, Fundamentals, and Disease, held December 8-10 at the Hong Kong University of Science and Technology. This Workshop is sponsored by the Institute for Advanced Study at the University of Science and Technology, The International Institute for Complex Adaptive Matter, The Croucher Foundation, the United States National Science Foundation and the United States National Cancer Institute.
Serie title from IAS Web page.
Performer(s): Speaker: Carlo Maley.
Event notes: Recorded on 9 Dec., 2009, Hong Kong University of Science and Technology.
Description: 1 streaming video file (51 min.) : digital, MP4 file, sd., col.
Series Title: IAS Workshop on evolution: foundations, fundamentals, and disease., Session 3,, The role of evolution in biological disease : cancer and cell dynamics ;, Talk no.1.
Responsibility: Carlo C. Maley.

Abstract:

"Our current theory of carcinogenesis is that mutant clones arise through genetic or epigenetic instability, and if they have a reproductive or survival advantage over other cells in the tumor, within their microenvironment, they will expand in the tumor in a selective sweep. Thus, we believe carcinogenesis is characterized by a series of selective sweeps. However, virtually all data on that process to date is cross-sectional, with observations of genetic diversity and large clonal expansions within neoplasms at a single time point ... I will present data that shows that there is genetic and epigenetic diversity within tumors, that clones do expand within tumors, that phenotypes evolve that are associated with increases in the reproduction and survival of those clones, and that therapies select for genetic mutations in tumors that make the clones resistant to the therapies."--Abstract.

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