RT Web Page DB /z-wcorg/ DS http://worldcat.org ID 834455893 LA English UL http://public.eblib.com/choice/publicfullrecord.aspx?p=1106389 T1 Evolution of extracellular matrix A1 Keeley, Fred W., Mecham, Robert P., PB Springer PP Berlin; New York YR 2013 SN 9783642360022 3642360025 3642360017 9783642360015 AB The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.