skip to content
Excitation-Contraction Coupling and Cardiac Contractile Force Preview this item
ClosePreview this item
Checking...

Excitation-Contraction Coupling and Cardiac Contractile Force

Author: Donald M Bers
Publisher: Dordrecht : Springer Netherlands, 2001.
Series: Developments in cardiovascular medicine, 237.
Edition/Format:   eBook : Document : English : Second editionView all editions and formats
Database:WorldCat
Summary:
How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Donald M Bers
ISBN: 9789401006583 940100658X
OCLC Number: 851390162
Description: 1 online resource (452 pages).
Contents: 1. Major cellular structures involved in E-C coupling --
Sarcolemma and transverse tubules --
Extracellular space --
Sarcoplasmic reticulum --
Mitochondria --
Myofilaments --
Connections to the extracellular matrix --
Other cellular constituents --
2. Myofilaments: The end effector of E-C Coupling --
Myofilament proteins --
Mechanism by which Ca activates contraction --
Acto-myosin ATPase --
The length-tension relationship --
The Ca sensitivity of the myofilaments --
Force-pCa relation in intact cardiac muscle --
Factors which influence the force-[Ca] relationship --
Force velocity curves --
3. Sources and sinks of activator calcium --
General Scheme of Ca cycle in cardiac myocyte --
Cellular volume conventions and Ca fluxes --
Ca buffering in the cytosol --
Ca requirements for activation of contraction --
Ca dynamics during a twitch --
Sources and sinks of Ca --
Ca removal during relaxation --
Ca influx vs SR Ca release in contractile activation --
Mitochondrial Ca transport --
4. Cardiac action potentials and ion channels --
Action potential & heterogeneity --
Resting Em Nernst potential & propagation --
Basic structure & function of ion channels --
Channel gating --
Na channels --
Ca channels --
K channels --
Cl channels --
Stretch-activated channels --
Non-selective channels --
Na/Ca exchange --
Na/K-ATPase --
Currents during ventricular action potential --
Pacemakers (AP Phase 4) --
Early and delayed afterdepolarizations --
Reentry of excitation --
5. Ca influx via sarcolemmal Ca channels --
Ca channel types --
Molecular characterization of Ca channels --
Ca channel selectivity and permeation --
Numbers of Ca channels --
Ca channel gating --
Amount of Ca entry via Ca channels --
Modulation of ICa by agonists and antagonists --?-adrenergic modulation of cardiac Ca current --
Other modulators of Ca current --
6. Na/Ca exchange and the sarcolemmal Ca-pump --
The sarcolemmal Ca-pump --
Na/Ca exchange --
Competition among Na/Ca exchange, sarcolemmal Ca-pump and SR Ca-pump during relaxation and at rest --
7. Sarcoplasmic reticulum Ca uptake, content and release --
SR Ca-pump --
SR Ca content: Assessment in intact cardiac muscle and myocytes --
SR Ca release channel or ryanodine receptor --
8. Excitation-contraction coupling --
Voltage-dependent Ca release (VDCR) and skeletal muscle E-C coupling --
Ca-induced Ca-release (CICR) --
Local control and CICR --
Other E-C coupling mechanisms in heart --
IP3-induced Ca release (IP3ICR) --
Summary --
9. Control of cardiac contraction by SR and sarcolemmal Ca fluxes --
Species, regional and developmental differences --
Biphasic contractions --
Rest decay and rest potentiation --
Force-frequency relationships --
10. Cardiac inotropy and Ca mismanagement --
Cardiac inotropy --
Ca mismanagement and negative inotropy --
Sites for induction of cardiac inotropy --
Conclusion --
References.
Series Title: Developments in cardiovascular medicine, 237.
Responsibility: by Donald M. Bers.
More information:

Abstract:

Offers a portrait of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. This book  Read more...

Reviews

Editorial reviews

Publisher Synopsis

'Since the first edition of Excitation-Contraction Coupling and Cardiac Contractile Force was published 10 years ago, it has become a classic. The second edition is stunning. It retains the zest and Read more...

 
User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.

Similar Items

Related Subjects:(2)

Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/851390162> # Excitation-Contraction Coupling and Cardiac Contractile Force
    a schema:CreativeWork, schema:Book, schema:MediaObject ;
    library:oclcnum "851390162" ;
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/25427264#Place/dordrecht> ; # Dordrecht
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/ne> ;
    schema:about <http://dewey.info/class/616.12/e23/> ;
    schema:about <http://id.worldcat.org/fast/1014893> ; # Medicine
    schema:about <http://id.worldcat.org/fast/847121> ; # Cardiology
    schema:bookEdition "Second edition." ;
    schema:bookFormat schema:EBook ;
    schema:creator <http://viaf.org/viaf/59715106> ; # Donald M. Bers
    schema:datePublished "2001" ;
    schema:description "How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile Force & endash; Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields."@en ;
    schema:description "1. Major cellular structures involved in E-C coupling -- Sarcolemma and transverse tubules -- Extracellular space -- Sarcoplasmic reticulum -- Mitochondria -- Myofilaments -- Connections to the extracellular matrix -- Other cellular constituents -- 2. Myofilaments: The end effector of E-C Coupling -- Myofilament proteins -- Mechanism by which Ca activates contraction -- Acto-myosin ATPase -- The length-tension relationship -- The Ca sensitivity of the myofilaments -- Force-pCa relation in intact cardiac muscle -- Factors which influence the force-[Ca] relationship -- Force velocity curves -- 3. Sources and sinks of activator calcium -- General Scheme of Ca cycle in cardiac myocyte -- Cellular volume conventions and Ca fluxes -- Ca buffering in the cytosol -- Ca requirements for activation of contraction -- Ca dynamics during a twitch -- Sources and sinks of Ca -- Ca removal during relaxation -- Ca influx vs SR Ca release in contractile activation -- Mitochondrial Ca transport -- 4. Cardiac action potentials and ion channels -- Action potential & heterogeneity -- Resting Em Nernst potential & propagation -- Basic structure & function of ion channels -- Channel gating -- Na channels -- Ca channels -- K channels -- Cl channels -- Stretch-activated channels -- Non-selective channels -- Na/Ca exchange -- Na/K-ATPase -- Currents during ventricular action potential -- Pacemakers (AP Phase 4) -- Early and delayed afterdepolarizations -- Reentry of excitation -- 5. Ca influx via sarcolemmal Ca channels -- Ca channel types -- Molecular characterization of Ca channels -- Ca channel selectivity and permeation -- Numbers of Ca channels -- Ca channel gating -- Amount of Ca entry via Ca channels -- Modulation of ICa by agonists and antagonists --?-adrenergic modulation of cardiac Ca current -- Other modulators of Ca current -- 6. Na/Ca exchange and the sarcolemmal Ca-pump -- The sarcolemmal Ca-pump -- Na/Ca exchange -- Competition among Na/Ca exchange, sarcolemmal Ca-pump and SR Ca-pump during relaxation and at rest -- 7. Sarcoplasmic reticulum Ca uptake, content and release -- SR Ca-pump -- SR Ca content: Assessment in intact cardiac muscle and myocytes -- SR Ca release channel or ryanodine receptor -- 8. Excitation-contraction coupling -- Voltage-dependent Ca release (VDCR) and skeletal muscle E-C coupling -- Ca-induced Ca-release (CICR) -- Local control and CICR -- Other E-C coupling mechanisms in heart -- IP3-induced Ca release (IP3ICR) -- Summary -- 9. Control of cardiac contraction by SR and sarcolemmal Ca fluxes -- Species, regional and developmental differences -- Biphasic contractions -- Rest decay and rest potentiation -- Force-frequency relationships -- 10. Cardiac inotropy and Ca mismanagement -- Cardiac inotropy -- Ca mismanagement and negative inotropy -- Sites for induction of cardiac inotropy -- Conclusion -- References."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/25427264> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/25427264#Series/developments_in_cardiovascular_medicine> ; # Developments in cardiovascular medicine ;
    schema:isPartOf <http://worldcat.org/issn/0166-9842> ; # Developments in Cardiovascular Medicine,
    schema:isSimilarTo <http://worldcat.org/entity/work/data/25427264#CreativeWork/> ;
    schema:name "Excitation-Contraction Coupling and Cardiac Contractile Force"@en ;
    schema:productID "851390162" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/851390162#PublicationEvent/dordrecht_springer_netherlands_2001> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/25427264#Agent/springer_netherlands> ; # Springer Netherlands
    schema:url <http://dx.doi.org/10.1007/978-94-010-0658-3> ;
    schema:workExample <http://dx.doi.org/10.1007/978-94-010-0658-3> ;
    schema:workExample <http://worldcat.org/isbn/9789401006583> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/851390162> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/25427264#Agent/springer_netherlands> # Springer Netherlands
    a bgn:Agent ;
    schema:name "Springer Netherlands" ;
    .

<http://experiment.worldcat.org/entity/work/data/25427264#Series/developments_in_cardiovascular_medicine> # Developments in cardiovascular medicine ;
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/851390162> ; # Excitation-Contraction Coupling and Cardiac Contractile Force
    schema:name "Developments in cardiovascular medicine ;" ;
    .

<http://id.worldcat.org/fast/1014893> # Medicine
    a schema:Intangible ;
    schema:name "Medicine"@en ;
    .

<http://id.worldcat.org/fast/847121> # Cardiology
    a schema:Intangible ;
    schema:name "Cardiology"@en ;
    .

<http://viaf.org/viaf/59715106> # Donald M. Bers
    a schema:Person ;
    schema:familyName "Bers" ;
    schema:givenName "Donald M." ;
    schema:name "Donald M. Bers" ;
    .

<http://worldcat.org/entity/work/data/25427264#CreativeWork/>
    a schema:CreativeWork ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/851390162> ; # Excitation-Contraction Coupling and Cardiac Contractile Force
    .

<http://worldcat.org/isbn/9789401006583>
    a schema:ProductModel ;
    schema:isbn "940100658X" ;
    schema:isbn "9789401006583" ;
    .

<http://worldcat.org/issn/0166-9842> # Developments in Cardiovascular Medicine,
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/851390162> ; # Excitation-Contraction Coupling and Cardiac Contractile Force
    schema:issn "0166-9842" ;
    schema:name "Developments in Cardiovascular Medicine," ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.