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Détails
| Format physique additionnel : | Online version: Exploiting chemical diversity for drug discovery. Cambridge, UK : Royal Society of Chemistry, c2006 (OCoLC)645929780 |
|---|---|
| Format : | Livre |
| Tous les auteurs / collaborateurs : |
Paul Allan Bartlett; Michael Entzeroth; Royal Society of Chemistry (Great Britain) |
| ISBN : | 9780854048427 0854048421 |
| Numéro OCLC : | 63703046 |
| Description : | xxiv, 420 p. : col. ill. ; 24 cm. |
| Contenu : | The use of polymer-assisted solution-phase synthesis and automation for the high-throughput preparation of biologically active compounds / Steven V. Ley, Mark Ladlow and Emma Vickerstaffe -- Accelerated chemistry : microwave, sonochemical, and fluorous phase techniques / Kristofer Olofsson, Peter Nilsson and Mats Larhed -- Biosynthesis of "unnatural" natural products / Yi Tang and Chaitan Khosla -- Combinatorial synthetic design : the balance of novelty and familiarity / A. Ganesan -- Compound collections : acquisition, annotation, and access / Reg Richardson -- Chemical diversity : definition and quantification / Alan C. Gibbs and Dimitris K. Agrafiotis -- Focused libraries : the evolution in strategy from large-diversity libraries to the focused library approach / Ruben Tommasi and Ivan Cornella -- Translating peptides into small molecules / Gerd Hummel, Ulrich Reineke and Ulf Reimer -- High-density plates, microarrays, microfluidics / Christof Fattinger and Gregor Dernick -- Fluorescence technologies for the investigation of chemical libraries / Eric Trinquet and Gérard Mathis -- The use of genetically engineered cell-based assays in in-vitro drug discovery / Renate Schnitzer and Wolfgang Sommergruber -- NMR-based screening : a powerful tool in fragment-based drug discovery / Jochen Klages, Murray Coles and Horst Kessler -- Screening chemical microarrays : methods and applications / Pappanaicken R. Kumaresan and Kit S. Lam -- Screen/counter-screen : early assessment of selectivity / Martyn N. Banks, Litao Zhang and John G. Houston -- Concepts for in vitro profiling : drug activity, selectivity and liability / Michael B. Bolger, Robert Fraczkiewicz, Michael Entzeroth and Boyd Steere -- In silico surrogates for in vivo properties : profiling for ADME and toxicological behavior / Michael B. Bolger, Robert Fraczkiewicz, Michael Entzeroth and Boyd Steere -- Uses of high content screening in chemical optimization / Francesca Casano, Zhuyin Li and Tina Garyantes. |
| Titre de collection : | RSC biomolecular sciences. |
| Responsabilité : | edited by Paul A. Bartlett, Michael Entzeroth. |
| Plus d’informations : |
Résumé :
Critiques
Synopsis de l’éditeur
...a timely and comprehensive overview of state-of-the-art developments in the diverse scientific and engineering disciplines...thoughtful preface...helpful and refreshing. Is an excellent and astonishingly complete compilation on this broad and demanding topic for current practitioners. Researchers in organic and medicinal chemistry, and in biological and pharmacological sciences, as well as those interested in allied computational and engineering disciplines, will benefit from the up-to-date coverage. High quality of the individual chapters. -- Angewandte Chemie, International Edition, 2007, 46, 22 (Andreas Link) Angewandte Chemie, International Edition Each chapter contains a comprehensive and up-to-date list of references as recent as 2005. An excellent introduction to evolving methodologies in the drug discovery process...excellent overview for medicinal chemists and all others involved in the drug discovery process. -- Journal of Medicinal Chemistry, 2007, Vol.50, No.2 (Carl Kaiser) Journal of Medicinal Chemistry - DO NOT SEND REVIEWS Excellent review articles covering advances in synthesis and screening, while providing a roadmap for how science meets technology to generate unique and diverse starting points for projects in drug discovery. Well organised and balanced between a high-level overview of lead identification and detailed descriptions of technologies...a strong framework for understanding how all of the pieces can fit together in the modern pharmaceutical endeavor...are written clearly and with a sufficient level of detail so that those working in technology-focused groups will find them meaningful. The book reduces a very complex area of drug discovery into meaningful categories and provides orientation to scientists confronted by the broad range of options in lead discovery. -- Journal of the American Chemical Society, Vol.128, No.51, 2006 (Terence A Kelly) Journal of the American Chemical Society (JACS) - NO LONGER ACCEPTING REVIEWS ...a timely and comprehensive overview of state-of-the-art developments in the diverse scientific and engineering disciplines...thoughtful preface...helpful and refreshing. Is an excellent and astonishingly complete compilation on this broad and demanding topic for current practitioners. Researchers in organic and medicinal chemistry, and in biological and pharmacological sciences, as well as those interested in allied computational and engineering disciplines, will benefit from the up-to-date coverage. High quality of the individual chapters. Each chapter contains a comprehensive and up-to-date list of references as recent as 2005. An excellent introduction to evolving methodologies in the drug discovery process...excellent overview for medicinal chemists and all others involved in the drug discovery process. Excellent review articles covering advances in synthesis and screening, while providing a roadmap for how science meets technology to generate unique and diverse starting points for projects in drug discovery. Well organised and balanced between a high-level overview of lead identification and detailed descriptions of technologies...a strong framework for understanding how all of the pieces can fit together in the modern pharmaceutical endeavor...are written clearly and with a sufficient level of detail so that those working in technology-focused groups will find them meaningful. The book reduces a very complex area of drug discovery into meaningful categories and provides orientation to scientists confronted by the broad range of options in lead discovery. Lire la suite...