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Extracellular matrix in development

Author: Douglas W DeSimone; Robert P Mecham
Publisher: Berlin ; New York : Springer, ©2013.
Series: Biology of extracellular matrix (Springer (Firm))
Edition/Format:   eBook : Document : EnglishView all editions and formats
Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix - secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and,  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Douglas W DeSimone; Robert P Mecham
ISBN: 9783642359354 3642359353 3642359345 9783642359347
OCLC Number: 834401615
Notes: Includes index.
Description: 1 online resource.
Contents: Part I. Informational Signals in Extracellular Matrix and Matrix Influences on Cell Movement in the Developing Embryo. The Glycocode: Translating Heparan Sulfate Fine Structure into Developmental Function / Adam B. Cadwallader, H. Joseph Yost --
Extracellular Matrix Dynamics in Early Development / Andras Czirok, Brenda J. Rongish, Charles D. Little --
Extracellular Matrix Functions in Amphibian Gastrulation / Bette J. Dzamba, Douglas W. DeSimone --
Part II. Extracellular Matrix-Direct Morphogenesis, Growth Factor Signaling, and Maintenance of the Stem Cell Niche. Cell-ECM Interactions and the Regulation of Epithelial Branching Morphogenesis / William P. Daley, Kenneth M. Yamada --
Interactions Between Neural Crest-Derived Cells and Extracellular Microenvironment During Cardiovascular Development / Sophie Astrof --
Engineered ECM Microenvironments and Their Regulation of Stem Cells / Yu Suk Choi, Andrew W. Holle, Adam J. Engler --
Part III. Model Organisms and the Lexicon of Developmental Signals Associated with the Extracellular Matrix. ECM in Hydra Development and Regeneration / Xiaoming Zhang, Michael P. Sarras Jr --
Extracellular Matrix Remodeling in Zebrafish Development / Nathan A. Mundell, Jason R. Jessen --
The Role of HA and Has2 in the Development and Function of the Skeleton / Peter J. Roughley, Pierre Moffatt.
Series Title: Biology of extracellular matrix (Springer (Firm))
Responsibility: Douglas W. DeSimone, Robert P. Mecham, editors.


This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function.  Read more...
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