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Extraskeletal effects of Vitamin D : a clinical guide

Author: Emilia Pauline Liao
Publisher: Cham, Switzerland : Humana Press, 2018.
Series: Contemporary endocrinology (Totowa, N.J.)
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
While the skeletal effects of vitamin D are well-documented, the role and importance of vitamin D outside of bone health has not been well-established. Vitamin D receptors are located in nearly every tissue of the body, and low levels of vitamin D are associated with a range of various diseases. This book provides an in-depth examination of these extraskeletal effects of vitamin D and the associations between  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Emilia Pauline Liao
ISBN: 9783319737423 3319737422
OCLC Number: 1032810108
Notes: Includes index.
Description: 1 online resource.
Contents: Intro; Series Editor Foreword; Preface; Contents; Contributors; Chapter 1: Vitamin D Biochemistry and Physiology; Introduction; Vitamin D Production; Vitamin D Metabolism; Transport of Vitamin D Metabolites in the Blood and Their Cellular Uptake; Vitamin D Mechanism of Action; Vitamin D Regulation of Cellular Function; Classic Vitamin D Target Tissues; Nonclassic Vitamin D Target Tissues; Regulation of Proliferation and Differentiation; Regulation of Hormone Secretion; Regulation of the Immune System; References; Chapter 2: Vitamin D and Autoimmune Diseases; Introduction; Vitamin D Deficiency Systemic Lupus ErythematosusType 1 Diabetes Mellitus; Multiple Sclerosis; Inflammatory Bowel Diseases; Rheumatoid Arthritis; Psoriasis; Other Autoimmune Diseases; Possible Underlying Mechanism; Conclusion; References; Chapter 3: Vitamin D and Infectious Diseases; Why Would Vitamin D Have an Impact on Infectious Diseases?; Historical Aspects; Cod Liver Oil; Light on Mycobacteria; Vitamin D Used in Treatment; Infections Where VD Has Been Hypothesized to Play a Role; Tuberculosis; TB Immunopathology in Relation to Vitamin D-Mediated Immunology Epidemiological Aspects: Vitamin D Status Among Patients with Active TB InfectionGenetic Aspects: Vitamin D Receptor and Susceptibility Toward TB; Intervention Studies Supplementing Patients with TB with Vitamin D; Other Respiratory Tract Infections; Intervention Studies on Respiratory Tract Infections; Methicillin-Resistant Staphylococcus aureus (MRSA) Carriage in Airways; Sepsis; Observational Studies on Vitamin D and Sepsis; Vitamin D Supplementation Trials; Human Immunodeficiency Virus; Association of Anti-retroviral Treatment (ART) and Vitamin D; Vitamin D Supplementation to HIV Infected Hepatitis C VirusAssociation of Vitamin D Deficiency with Disease Severity and Sustained Viral Response; Vitamin D Supplementation and Hepatitis; Hepatitis C and HIV Coinfection; Vitamin D as Risk Marker for Infection and Role in Antimicrobial Treatment and Prevention; References; Chapter 4: Vitamin D Hormone Action in the Endocrine Tissue: Implications for Prostate and Breast Carcinoma; Introduction; Vitamin D Metabolism; Synthesis, Degradation, and Roles and Regulation of Key Enzymes; Vitamin D Metabolism in the Prostate Transcription Regulation by VDR: Domain Structure and Roles for Ligands, DNA Response Elements, and CoregulatorsFunctional Domains of VDR and Inter-domain Allostery; Naturally Occurring VDR Ligands; Calcitriol, Calcidiol, and Secondary Bile Acids; Agonist Actions of Calcitriol and Calcidiol on VDR: Analysis by Molecular Docking; Gene Regulation by VDR: Roles for Coregulators and DNA Response Elements; Interplay of Androgen and Vitamin D in Prostate: Impacts on Cell Proliferation, Vitamin D Metabolism, and the AR Pathway; Effects on Cell Cycle Regulation and E2F1, a Key Cell Cycle Regulator
Series Title: Contemporary endocrinology (Totowa, N.J.)
Responsibility: Emilia Pauline Liao, editor.

Abstract:

While the skeletal effects of vitamin D are well-documented, the role and importance of vitamin D outside of bone health has not been well-established. This book provides an in-depth examination of  Read more...

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