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  E-mail Message: I thought you might be interested in this item at http://www.worldcat.org/oclc/117451181 Title: Factors influencing testosterone metabolism by anuran larvae. Publisher: ISBN/ISSN: 0022-104X OCLC:117451181

  
  

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Factors influencing testosterone metabolism by anuran larvae.

Author:	TB Hayes; P Licht
Edition/Format:	Article : English
Publication:	The Journal of experimental zoology, 1995 Feb 1; 271(2): 112-9
Database:	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Other Databases:	ArticleFirst; British Library Serials
Summary:	The effects of experimental conditions--steroid concentration, temperature, treatment duration, tadpole density, and delivery mode--on testosterone (T) metabolic rates were examined in larval anurans. T uptake into tadpoles was measured by scintillation counting of [3H]T and metabolism of T was studied by thin layer chromatography in two anuran species, the African clawed frog (Xenopus laevis) and the western toad (Bufo boreas). T was extensively metabolized by both species, but the effects of each experimental condition on T metabolism varied between species. In the study of delivery mode, tadpoles injected with T dissolved in saline metabolized T faster than animals in groups where the steroid was added directly to the water. Animals injected with T dissolved in oil metabolized T the slowest, but T was short-lived in all cases. The current study demonstrates that concentration, temperature, treatment duration, tadpole density, and delivery mode may all affect steroid metabolic rates, but these effects vary between species in unpredictable ways. Since steroid metabolism may either activate or deactivate steroids, these factors are important in understanding the potency of steroids in tadpoles. A review of the literature dealing with steroid effects in anuran larvae illustrates these problems.  Read more...
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