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Females are mosaics : X inactivation and sex differences in disease

Author: Barbara R Migeon
Publisher: Oxford : Oxford University Press, 2014.
Edition/Format:   eBook : Document : English : Second editionView all editions and formats
Summary:
Women can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome, females have two X chromosomes in every cell. Much has been written about the Y chromosome and its role in inducing maleness. This is the only book about the X chromosome as a key to female development and the role of X-related factors in the etiology  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Migeon, Barbara R.
Females are mosaics.
(DLC) 2013017154
(OCoLC)841556714
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Barbara R Migeon
ISBN: 9780199927548 0199927545
OCLC Number: 859536749
Description: 1 online resource (pages)
Contents: Sex differences in disease --
Evolution of the human sex chromosomes and a portrait of the human X --
X chromosome dosage compensation : an overview --
The discovery of X chromosome inactivation --
Experimental models for X inactivation studies --
Theme 1 : the initial step : creating the active and inactive X --
Theme 2 : subsequent steps : spreading and maintaining inactivation --
Variations 1 : evolution of the X inactivation center --
Variations 2 : stability of the inactive X --
Variations 3 : choice of active X --
The single active X --
Mosaicism --
Epimutations, chromatin disorders and sex differences in phenotype --
Determinants of female phenotypes.
Responsibility: Barbara R. Migeon.

Abstract:

This is the only book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. This new edition reflects research  Read more...

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"This book provides a balanced overview of the field to date, allowing newcomers to the field to concentrate on the recent literature necessity...The information in the book is up-to-date and a Read more...

 
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