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Fetal therapy : scientific basis and critical appraisal of clinical benefits

Author: Mark Kilby; Anthony Johnson; Dick Oepkes
Publisher: Cambridge, UK ; New York : Cambridge University Press, 2013.
Series: Cambridge medicine (Series)
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
"Fetal treatment, particularly complex fetal therapy, is an emergent and expanding field. This comprehensive text focuses on areas of fetal disease and pathophysiology that can be treated in utero and the benefits and problems with such therapy. Both medical (non-invasive) and surgical procedures are discussed, drawing on the expertise of an internationally renowned author team. Each chapter includes a comprehensive  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Fetal therapy.
Cambridge, UK ; New York : Cambridge University Press, 2013
(DLC) 2012018847
(OCoLC)793221665
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Mark Kilby; Anthony Johnson; Dick Oepkes
ISBN: 1139842390 9781139842396 9780511997778 0511997779 9781139844758 113984475X 9781139840019 1139840010 9781283899390 1283899396
OCLC Number: 826685681
Description: 1 online resource (xv, 453 pages) : illustrations (chiefly color).
Contents: Cover; HalfTitle; Title; Copyright; Dedication; Contents; Contributors; Foreword; Preface; Section 1 General principles; 1 The rationale for fetal therapy; Introduction; Innovative surgery versus randomized trials; Hemolytic disease of the fetus and newborn (HDFN); Twin-to-twin transfusion syndrome (TTTS); Myelomeningocele (MMC); Congenital diaphragmatic hernia (CDH); Conclusion; 2 Insights into pathogenesis of adult cardiovascular disease from fetal animal studies; Introduction; The epidemic of non-communicable disease: relating epidemiology to animal models; The DOHaD concept. Human and animal evidenceAnimal models for translation of science to human development; Human studies; Small rodent models; Developmental models independent of the mother; Large mammalian models; Prenatal adaptive responses; Conceptual issues; Cardiovascular control and growth; The timing of birth; Steps on the pathway to fetal adaptive responses; Maternal adaptations to pregnancy; The role of the placenta; Epigenetic modifications; Conclusion and future considerations; Acknowledgments; 3 Human embryology: molecular mechanisms of embryonic disease; How do embryos develop? The Hedgehog signaling pathwayShh as a morphogen in the neural tube and limb bud; The Wnt signaling pathway; The TGFß signaling pathway; The FGF signaling pathway; The notch pathway; Summary; Acknowledgments; 4 Ethics of fetal therapy; Introduction; An ethical framework for fetal therapy; Medical ethics; The ethical principle of beneficence; The ethical principle of respect for autonomy; The ethical concept of the fetus as a patient; Research ethics; Criteria for innovation, clinical investigation, and the responsible transition to clinical practice; Ethical criteria for innovation. Ethical criteria for clinical investigationCriteria for responsible transition to clinical practice; The informed consent process; Conclusion; 5 Fetal therapy choices: about risks, emotions, and the doctor's role in the decision-making process; Introduction; The decision problem: the case of Mrs. D. and her unborn son with a pulmonary malformation; Information and decision-making; Limits to processing and understanding information; Emotions, intuition, and decision-making; Intuition and rationality; Emotions; Immediate emotions; Anticipated emotions; Perceiving and understanding risks. Shared decision-making and the doctor as counselorCommunicating risks; Using verbal terms to express probabilities; Using numbers to express uncertainty; Using graphics to express probabilities; Using verbal terms to express probabilities; Using numbers to express uncertainty; Using graphics to express probabilities; Clarifying values and preferences; Supporting decision-making: what to choose?; Section 2 Fetal disease: pathogenesis and principles; 6 Red cell alloimmunization; Introduction; Red cell alloimmunization in pregnancy; Risk factors for fetomaternal hemorrhage; Rhesus genetics.
Series Title: Cambridge medicine (Series)
Responsibility: edited by Mark D. Kilby, Dick Oepkes, Anthony Johnson.

Abstract:

Covers the latest insights any fetal specialist needs and provides essential knowledge for professionals caring for women with high-risk pregnancies.  Read more...

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'It is both scientific and pragmatic and should satisfy a variety of curiosities in this fascinating field of therapeutic medicine. As such, it is a "must have" for fetal medicine specialists and Read more...

 
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