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Filaggrin : basic science, epidemiology, clinical aspects and management

Author: Jacob P Thyssen; Howard I Maibach
Publisher: Heidelberg : Springer, [2014]
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes. While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Filaggrin. Thyssen, epidemiology, clinical aspects and management
(OCoLC)880132168
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Jacob P Thyssen; Howard I Maibach
ISBN: 9783642543791 3642543790
OCLC Number: 881289646
Description: 1 online resource
Contents: Function of Filaggrin and Its Metabolites --
Morphology of Filaggrin-Depleted Epidermis --
Stratum Corneum Lipids and Filaggrin --
Inflammatory-Driven Depletion of Filaggrin Proteins --
Immune Activity and Vitamin D --
Filaggrin-2 --
Animal Models --
In Vitro Models of Filaggrin-Associated Diseases --
Mapping Posttranslational Regulation of Filaggrin Using Phosphoproteomics --
Noninvasive Detection of Filaggrin Molecules by Raman Spectroscopy --
Filaggrin Genotyping --
Prevalence of Filaggrin Gene Mutations: An Evolutionary Perspective --
Filaggrin Gene Mutations in Asian Races --
Filaggrin Gene Loss-of-Function Mutations and Exposure to Endocrine Disrupting Environmental Chemicals --
Filaggrin Mutations and the Atopic March --
Atopic Dermatitis --
Asthma --
Filaggrin Mutations, Skin Barrier Dysfunction, and Sensitization in Allergic Rhinitis --
Filaggrin and Non-cutaneous Disease: Food Allergy --
Filaggrin in Canine Skin --
Ichthyosis Vulgaris and Other Disorders of Cornification --
Xerosis Means "Dry Skin": Mechanisms, Skin Conditions, and Its Management --
Allergic Contact Dermatitis --
Irritant Contact Dermatitis --
Hand Eczema --
Filaggrin in Psoriasis --
Filaggrin and Skin Infections --
Atopic Dermatitis and Skin Cancer --
Filaggrin Gene Mutations: A Clinician's Perspective --
Filaggrin, the Skin Barrier, and Diabetes --
The Eye and Filaggrin --
Filaggrin Dysfunction and Its Association with Inflammatory Conditions of the GI Tract --
Filaggrin, Human Papillomavirus, and the Cervix --
Antibodies Against Citrullinated Proteins and Filaggrin --
Filaggrin and the Oral Mucosa --
Therapeutics and Other Interventions.
Responsibility: edited by Jacob P. Thyssen, Howard Maibach.

Abstract:

Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their  Read more...

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