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Fluorine in pharmaceutical and medicinal chemistry : from biophysical aspects to clinial applications

Author: Véronique Gouverneur; Klaus Müller
Publisher: London : Imperial College Press ; Singapore : Dist. by World Scientific Press, 2012.
Series: Molecular medicine and medicinal chemistry, 6.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Fluorine in pharmaceutical and medicinal chemistry.
London : Imperial College Press ; Singapore : Dist. by World Scientific Press, 2012
(OCoLC)751735680
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Véronique Gouverneur; Klaus Müller
ISBN: 9781848166363 1848166362
OCLC Number: 795631982
Description: 1 online resource (xxiii, 546 pages) : illustrations (some color).
Contents: 1. Synthesis and properties of fluorinated nucleobases in DNA and RNA / Holger Gohlke, Jelena Bozilovic and Joachim W. Engels --
2. Molecular interactions of fluorinated amino acids within the hydrophobic core of a coiled coil peptide / Toni Vagt, Mario Salwiczek and Beate Koksch --
3. Probing the binding affinity and proteolytic stability of trifluoromethyl peptide mimics as protease inhibitors / Matteo Zanda [and others] --
4. Trifluoromethyl-substituted [symbol]-amino acids as solid-state [symbol]F NMR labels for structural studies of membrane-bound peptides / Vladimir S. Kubyshkin [and others] --
5. Fluorine-containing pharmaceuticals / Steve Swallow --
6. Applications of pentafluorosulfanyl substitution in life sciences research / John T. Welch --
7. Strategic incorporation of fluorine into taxoid anticancer agents / Antonella Pepe, Liang Sun and Iwao Ojima --
8. Synthesis and antiviral, antitumour activities of fluorinated sugar nucleosides / Feng Zheng, Xiao-Long Qiu and Feng-Ling Qing --
9. Synthesis of fluorinated neurotransmitter analogues / Margit Winkler and David O'Hagan --
10. [symbol]F-radionuclide chemistry / Romain Bejot and Veronique Gouverneur --
11. [symbol]F-labelled tracers for PET oncology and neurology applications / Sajinder K. Luthra and Edward G. Robins --
12. [symbol]F NMR: clinical and molecular imaging applications / Vikram D. Kodibagkar [and others].
Series Title: Molecular medicine and medicinal chemistry, 6.
Responsibility: Véronique Gouverneur, Klaus Müller, editors.

Abstract:

Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging. This book  Read more...

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