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Folic acid and folates

Author: Gerald Litwack
Publisher: London : Academic Press, 2008.
Series: Vitamins and hormones, v. 79.
Edition/Format:   eBook : Document : English : 1st edView all editions and formats
Summary:
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Folic acid and folates
(OCoLC)225874148
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Gerald Litwack
ISBN: 9780080921266 0080921264 9780123742322 0123742323
OCLC Number: 317980491
Description: 1 online resource (xviii, 443 pages, [16] pages of plates) : illustrations (some color).
Contents: ""Contents""; ""Contributors""; ""Preface""; ""Chapter 1: Folate-Mediated One-Carbon Metabolism""; ""I. Overview""; ""II. Introduction to Cytoplasmic One-Carbon Metabolism""; ""III. Introduction to Mitochondrial One-Carbon Metabolism""; ""IV. Nuclear Folate-Mediated One-Carbon Metabolism""; ""Acknowledgments""; ""References""; ""Chapter 2: Mathematical Models of Folate-Mediated One-Carbon Metabolism""; ""I. Introduction""; ""II. Structure and Function of the Cycles""; ""III. Why Mathematical Modeling?""; ""IV. Model Development""; ""V. Blood Versus Intracellular Metabolite Concentrations"" ""VI. Modeling Gene-Gene and Gene-Environment Interactions""""VII. Modeling and Simulation have Revealed Novel Homeostatic Mechanisms""; ""VIII. Steady States and Fluctuations""; ""IX. Conclusions""; ""Acknowledgments""; ""References""; ""Chapter 3: Folate Deprivation, the Methionine Cycle, and Alzheimer's Disease""; ""I. Introduction""; ""II. Folate Metabolism, the Transmethylation Pathway, and AD""; ""III. The Transsulfuration Pathway-Homocysteine Elimination and Glutathione Metabolism""; ""References""; ""Chapter 4: Molecular Mechanisms of Adaptation to Folate Deficiency"" ""I. Folate Metabolism""""II. Pathological States Associated with Folate Deficiency or Nutritional Folate Insufficiency""; ""III. Molecular Mechanisms of Adaptation to Folate Deprivation""; ""References""; ""Chapter 5: Structure and Function of the Reduced Folate Carrier: A Paradigm of a Major Facilitator Superfamily Mammalian Nutrient Transporter""; ""I. Introduction""; ""II. MFS of Transporters""; ""III. Folate Transport in Tissue Folate Homeostasis and Physiology: Role of Multiple Transport Systems for Folate Uptake and Efflux""; ""IV. Role of RFC in Antifolate Chemotherapy"" ""V. Functional Properties of RFC""""VI. Biochemistry of RFC""; ""VII. Cloning of RFC cDNAs That Restore Transport to Transport-Impaired Cultured Cells""; ""VIII. Topological Structure of RFC""; ""IX. Insights into Structural and Functional Determinants of RFC from Studies of Mutant RFC Proteins""; ""X. Conclusions""; ""Acknowledgment""; ""References""; ""Chapter 6: Renal Conservation of Folates: Role of Folate Transport Proteins""; ""I. Introduction""; ""II. Physicochemical Properties, Protein Binding, and Water Solubility""; ""III. Role of Folates in Genomic Stability"" ""IV. Folates and the Kidney""""V. Folate Transport Proteins""; ""VI. Localization of Putative Folate Transporters in Kidney""; ""VII. Clinical Studies of Renal Handling of Folates and Antifolates""; ""VIII. Role of Renal Folate Conservation in Ethanol-Related Folate Deficiency""; ""IX. Role of Folate Transport Processes in Renal Conservation of Folates and Antifolates""; ""References""; ""Chapter 7: Exploitation of the Folate Receptor in the Management of Cancer and Inflammatory Disease""; ""I. Introduction""; ""II. Aspects of the FR""; ""III. Exploitation of the FR for Disease Management""
Series Title: Vitamins and hormones, v. 79.
Responsibility: editor-in-chief, Gerald Litwack.

Abstract:

Covers the fields of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. This title presents reviews of interest to endocrinologists, biochemists,  Read more...

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