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Forensic DNA typing : biology and technology behind STR markers

Author: John M Butler
Publisher: San Diego, Calif. ; London : Academic, 2000.
Edition/Format:   Print book : EnglishView all editions and formats

This title provides crime laboratories and legal professionals with information on short tandem repeat markers that form the basis of the FBI and Europe-wide DNA database.


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Document Type: Book
All Authors / Contributors: John M Butler
ISBN: 012147951X 9780121479510
OCLC Number: 223032110
Description: 320 pages
Contents: Foreword; Introduction; Acknowledgements; Overview and History of DNA Typing; Biology; DNA Biology Review; Sample Collection and Preparation (DNA Extraction and Quantification); The Polymerase Chain Reaction (DNA Amplification); Commonly Used Short Tandem Repeat Markers; Biology of STRs: Stutter Products, Non-Template Addition, Microvariants, Null Alleles, and Mutation Rates; Forensic Issues: Degraded DNA, PCR Inhibition, Contamination, and Mixed Samples; Additional DNA Markers: Amelogenin, Y-Chromosome STRs, mtDNA, SNPs, Alu Repeats; Technology; DNA Separation Methods: Slab-Gel and Capillary Electrophoresis; DNA Detection Methods: Fluorescent Dyes and Silver Staining; The ABI Prism 310 Genetic Analyzer; The Hitachi FMBIO II Fluorescence Imaging System; STR Genotyping Issues; Laboratory Validation; New Technologies and Automation; Combined DNA Index System (CODIS) and the Use of DNA Database; Biology, Technology and Genetics; DNA Testing in High-Profile Cases; Appendix I: Reported STR Alleles: Sizes and Sequences; Appendix II: CEPH Family Study; Appendix III: DNA Advisory Board Quality Assurance Standards; Appendix IV: Suppliers of DNA Analysis Equipment, Products, or Services; Index;
Responsibility: John M. Butler.


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"...a well written and informative book...The author has succeeded in presenting complex biological and technical information on STR markers in a way that allows the reader to clearly visualize and Read more...

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