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Foye's principles of medicinal chemistry

Author: William O Foye; Thomas L Lemke; David A Williams
Publisher: Philadelphia : Lippincott Williams & Wilkins, ©2008.
Edition/Format:   Book : English : 6th edView all editions and formats
Database:WorldCat
Summary:
This comprehensive text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist. A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems.  Read more...
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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: William O Foye; Thomas L Lemke; David A Williams
ISBN: 9780781768795 0781768799
OCLC Number: 145942325
Description: xiv, 1377 pages, 8 pages of plates : illustrations (some color) ; 29 cm
Contents: Historical perspective of medicinal chemistry / John L. Neumeyer --
pt. I: Principles of drug discovery --
Chapter 1: Drug discovery from natural products / A. Douglas Kinghorn --
Chapter 2: Drug design and relationship of functional groups to pharmacologic activity / James J. Knittel and Robin M. Zavod --
Chapter 3: Molecular modeling and in Silico drug design / Xiang-Qun (Sean) Xie --
Chapter 4: Receptors and drug action / Timothy A. Maher and David A. Johnson --
Chapter 5: Drug discovery through enzyme inhibition / Stephen Kerr --
Chapter 6: Pharmaceutical biotechnology-from nucleic acids to personalized medicine / Ronald E. Reid and Robert D. Sindelar --
Chapter 7: Peptide and protein drugs / Michael Mokotoff --
Chapter 8: Antisense therapeutic agents / Marilyn Speedie --
Chapter 9: Physicochemical and biopharmaceutical properties of drug substances and pharmacokinetics / Sunil S. Jambhekar --
Chapter 10: Drug metabolism / David A. Williams --
Chapter 11: U.S. drug regulation: an overview / Douglas --
Part II: Drug receptors affecting neurotransmission and enzymes as catalytic receptors : overview of Drug Receptors: A Perspective / David J. Triggle --
Chapter 12: Drugs affecting cholinergic neurotransmission / E. Kim Fifer --
Chapter 13: Adrenergic receptors and drugs affecting adrenergic neurotransmission / Robert K. Griffith --
Chapter 14: Serotonin receptors and drugs affecting serotonergic neurotransmission / Richard A. Glennon and Malgorzata Dukat-Glennon --
Chapter 15: Amino acid neurotransmitters in the central nervous system / Timothy J. Maher --
Chapter 16: Inhibitors of nerve conduction: local anesthetics / Matthias C. Lu --
Chapter 17: Phosphodiesterase inhibitors / Kevin Dalby --
Part III: Pharmacodynamic Agents --
Section 1: Drugs affecting central nervous system --
Chapter 18: General anesthetics / Timothy J. Maher --
Chapter 19: Sedative-hypnotics / William Soine --
Chapter 20: Antiseizure agents / Barbara Leduc --
Chapter 21: Antidepressants / David A. Williams --
Chapter 22: Psychotherapeutic drugs: antipsychotic and anxiolytic agents / Raymond G. Booth --
Chapter 23: Hallucinogens, stimulants and related drugs of abuse / Richard A. Glennon --
Chapter 24: Opioid analgesics / David S. Fries --
Chapter 25: Drugs used to treat neuromuscular disorders: antiparkinsonian and spasmolytic agents / Raymond G. Booth. Section 2: Drugs affecting the cardiovascular system --
Chapter 26: Cardiac agents: Cardiac glycosides, antianginal, and antiarrhythmic drugs / Ahmed S. Mehanna --
Chapter 27: Diuretics / Gary O. Rankin --
Chapter 28: Angiotensin converting enzyme inhibitors, antagonists and calcium blockers / Marc Harrold --
Chapter 29: Central and peripheral sympatholytics and vasodilators / David A. Williams --
Chapter 30: Antihyperlipoproteinemics and inhibitors of cholesterol biosynthesis / Marc Harrold --
Chapter 31: Antithrombotics, thrombolytics, coagulants, and plasma extenders / Matthias C. Lu and Thomas L. Lemke --
Section 3: Drugs affecting the hormonal systems --
Chapter 32: Insulin and drugs used for the treatment of diabetes / Robin M. Zavod, John L. Krstenansky, and Bruce L. Currie --
Chapter 33: Adrenocorticoids / Duane D. Miller, Robert W. Brueggemeier and James T. Dalton --
Chapter 34: Thyroid function and thyroid drugs / Ali R. Banijamali --
Chapter 35: Calcium homeostasis / Robin M. Zavod --
Section 4: Drugs affecting the immune systems --
Chapter 36: Nonsteroidal anti-inflammatory drugs / Wendel L. Nelson --
Chapter 37: Antihistamines and related antiallergic and antiulcer agents --
Section 5: Chemotherapeutic agents --
Chapter 38: Antibiotics and antimicrobial agents / Lester A. Mitscher, Thomas L. Lemke, and Elmer J. Gentry --
Chapter 39: Antiparasitic agents: Thomas L. Lemke --
Chapter 40: Antifungal agents / Robert K. Griffith --
Chapter 41: Antimycobacterial agents /Thomas L. Lemke --
Chapter 42: Cancer and chemotherapy / Victoria F. Roche --
Chapter 43: Antiviral agents and protease inhibitors / Patrick M. Woster --
Part IV: Disease state management --
Chapter 44: Asthma and chronic obstructive pulmonary disease S. William Zito --
Chapter 45: Men' Health / Duane D. Miller, Robert W. Brueggermeier, and James T. Dalton --
Chapter 46: Women's Health / Robin M. Zavod.
Other Titles: Principles of medicinal chemistry
Responsibility: edited by Thomas L. Lemke, David A. Williams ; assistant editors, Victoria F. Roche, S. William Zito [and others].
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Abstract:

Helps to meet the changing curricula of medicinal chemistry courses. This title places emphasis on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a  Read more...

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schema:description"Section 2: Drugs affecting the cardiovascular system -- Chapter 26: Cardiac agents: Cardiac glycosides, antianginal, and antiarrhythmic drugs / Ahmed S. Mehanna -- Chapter 27: Diuretics / Gary O. Rankin -- Chapter 28: Angiotensin converting enzyme inhibitors, antagonists and calcium blockers / Marc Harrold -- Chapter 29: Central and peripheral sympatholytics and vasodilators / David A. Williams -- Chapter 30: Antihyperlipoproteinemics and inhibitors of cholesterol biosynthesis / Marc Harrold -- Chapter 31: Antithrombotics, thrombolytics, coagulants, and plasma extenders / Matthias C. Lu and Thomas L. Lemke -- Section 3: Drugs affecting the hormonal systems -- Chapter 32: Insulin and drugs used for the treatment of diabetes / Robin M. Zavod, John L. Krstenansky, and Bruce L. Currie -- Chapter 33: Adrenocorticoids / Duane D. Miller, Robert W. Brueggemeier and James T. Dalton -- Chapter 34: Thyroid function and thyroid drugs / Ali R. Banijamali -- Chapter 35: Calcium homeostasis / Robin M. Zavod -- Section 4: Drugs affecting the immune systems -- Chapter 36: Nonsteroidal anti-inflammatory drugs / Wendel L. Nelson -- Chapter 37: Antihistamines and related antiallergic and antiulcer agents -- Section 5: Chemotherapeutic agents -- Chapter 38: Antibiotics and antimicrobial agents / Lester A. Mitscher, Thomas L. Lemke, and Elmer J. Gentry -- Chapter 39: Antiparasitic agents: Thomas L. Lemke -- Chapter 40: Antifungal agents / Robert K. Griffith -- Chapter 41: Antimycobacterial agents /Thomas L. Lemke -- Chapter 42: Cancer and chemotherapy / Victoria F. Roche -- Chapter 43: Antiviral agents and protease inhibitors / Patrick M. Woster -- Part IV: Disease state management -- Chapter 44: Asthma and chronic obstructive pulmonary disease S. William Zito -- Chapter 45: Men' Health / Duane D. Miller, Robert W. Brueggermeier, and James T. Dalton -- Chapter 46: Women's Health / Robin M. Zavod."@en
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