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Fragment-based approaches in drug discovery

Author: Wolfgang Jahnke; Daniel A Erlanson
Publisher: Weinheim : Wiley-VCH, ©2006.
Series: Methods and principles in medicinal chemistry, 34.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:

This first systematic summary of the impact of such approaches on the drug development process, Fragment-based Approaches in Drug Discovery provides essential information that was previously  Read more...

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Document Type: Book
All Authors / Contributors: Wolfgang Jahnke; Daniel A Erlanson
ISBN: 9783527312917 3527312919
OCLC Number: 67873894
Description: xxii, 369 pages : illustrations.
Contents: The concept of fragment-based drug discovery / Daniel A. Erlanson and Wolfgang Jahnke --
Multivalency in ligand design / Vijay M. Krishnamurthy, Lara A. Estroff, and George M. Whitesides --
Entropic consequences of linking ligands / Christopher W. Murray and Marcel L. Verdonk --
Location of binding sites on proteins by the multiple solvent crystal structure method / Dagmar Ringe and Carla Mattos --
Cheminformatics approaches to fragment-based lead discovery / Tudor I. Oprea and Jeffrey M. Blaney --
Structural fragments in marketed oral drugs / Michal Vieth and Miles Siegel --
Fragment docking to proteins with the multi-copy simultaneous search methodology / Collin M. Stultz and Martin Karplus --
NMR-guided fragment assembly / Daniel S. Sem --
SAR by NMR : an analysis of potency gains realized through fragment-linking and fragment-elaboration strategies for lead generation / Philip J. Hajduk, Jeffrey R. Huth, and Chaohong Sun --
Pyramid : an integrated platform for fragment-based drug discovery / Thomas G. Davies, Rob L.M. van Montfort, Glyn Williams, and Harren Jhoti --
Fragment-based lead discovery and optimization using X-ray crystallography, computational chemistry, and high-throughput organic synthesis / Jeff Blaney, Vicki Nienaber, and Stephen K. Burley --
Synergistic use of protein crystallography and solution-phase NMR spectroscopy in structure-based drug design : strategies and tactics / Cele Abad-Zapatero, Geoffrey F. Stamper, and Vincent S. Stoll --
Ligand SAR using electrospray ionizing mass spectrometry / Richard H. Griffey and Eric E. Swayze --
Tethering / Daniel A. Erlanson, Marcus D. Ballinger, and James A. Wells --
Click chemistry for drug discovery / Stefanie Röper and Hartmuth C. Kolb --
Dynamic combinatorial diversity in drug discovery / Matthias Hochgürtel and Jean-Marie Lehn.
Series Title: Methods and principles in medicinal chemistry, 34.
Responsibility: edited by Wolfgang Jahnke and Daniel A. Erlanson.

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'...this is indispensable reading for drug discovery researchers in the pharma and biotech sector.' (Anticancer Research, 2007)

 
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