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Fragment-based drug discovery : a practical approach

Autore: Edward Zartler; Michael Shapiro
Editore: Chichester, U.K. : John Wiley & Sons, 2008.
Edizione/Formato:   book_printbook : EnglishVedi tutte le edizioni e i formati
Banca dati:WorldCat
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Fragment-based drug discovery is a faster, cheaper, smarter way to do drug discovery. Emphasizing practical guidance, with procedures, case studies, practical tips, and contributions from industry,  Per saperne di più…

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Tipo documento: Book
Tutti gli autori / Collaboratori: Edward Zartler; Michael Shapiro
ISBN: 9780470058138 0470058137
Numero OCLC: 233544904
Descrizione: ix, 285 pages : illustrations ; 25 cm
Contenuti: Introduction to fragment-based drug discovery / Mike Cherry and Tim Mitchell --
Designing a fragment process to fit your needs / Edward R. Zartler and Michael J. Shapiro --
Assembling a fragment library / Mark Brewer [and others] --
Practical aspects of using NMR in fragment-based screening / Johan Schultz --
Application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses / William J. Metzler [and others] --
Target-immobilized NMR screening : validation and extension to membrane proteins / Virginie Früh, Robert J. Heetebrij, and Gregg Siegal --
In situ fragment-based medicinal chemistry : screening by mass spectrometry / Sally-Ann Poulsen and Gary H. Kruppa --
Computational approaches to fragment and substructure discovery and evaluation / Eelke van der Horst and Adriaan P. IJzerman --
Virtual fragment scanning : current trends, applications and web-based tools / Bradley Feuston [and others] --
Capture methods for fragment-based lead discovery / Stig K. Hansen and Daniel A. Erlanson --
Identification of high affinity [beta]-secretase inhibitors using fragment-based lead generation / Jeffrey S. Albert and Philip D. Edwards.
Responsabilità: editors, Edward R. Zartler, Michael J. Shapiro.

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"This is a useful book for readers already familiar with the basic aspects of drug design and discovery." (ChemMedChem, October 2009) "This book provides an excellent resource for those in Per saperne di più…

 
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