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Fragment-based drug discovery : a practical approach

Author: Edward Zartler; Michael Shapiro; Wiley InterScience (Online service)
Publisher: Chichester, U.K. : John Wiley & Sons, 2008.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. ℗¡ Fragment-Based Drug Discovery: A Practical  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Fragment-based drug discovery.
Chichester, U.K. : John Wiley & Sons, 2008
(DLC) 2008027930
(OCoLC)233544904
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Edward Zartler; Michael Shapiro; Wiley InterScience (Online service)
ISBN: 9780470721551 0470721553 9780470721568 0470721561 1282342754 9781282342750
OCLC Number: 299043657
Description: 1 online resource (ix, 285 pages) : illustrations
Contents: Introduction to fragment-based drug discovery / Mike Cherry and Tim Mitchell --
Designing a fragment process to fit your needs / Edward R. Zartler and Michael J. Shapiro --
Assembling a fragment library / Mark Brewer [and others] --
Practical aspects of using NMR in fragment-based screening / Johan Schultz --
Application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses / William J. Metzler [and others] --
Target-immobilized NMR screening : validation and extension to membrane proteins / Virginie Früh, Robert J. Heetebrij, and Gregg Siegal --
In situ fragment-based medicinal chemistry : screening by mass spectrometry / Sally-Ann Poulsen and Gary H. Kruppa --
Computational approaches to fragment and substructure discovery and evaluation / Eelke van der Horst and Adriaan P. IJzerman --
Virtual fragment scanning : current trends, applications and web-based tools / Bradley Feuston [and others] --
Capture methods for fragment-based lead discovery / Stig K. Hansen and Daniel A. Erlanson --
Identification of high affinity [beta]-secretase inhibitors using fragment-based lead generation / Jeffrey S. Albert and Philip D. Edwards.
Responsibility: editors, Edward R. Zartler, Michael J. Shapiro.

Abstract:

Fragment-based drug discovery is a faster, cheaper, smarter way to do drug discovery. Emphasizing practical guidance, with procedures, case studies, practical tips, and contributions from industry,  Read more...

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"This is a useful book for readers already familiar with the basic aspects of drug design and discovery." (ChemMedChem, October 2009) "This book provides an excellent resource for those in Read more...

 
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