skip to content
Functional analysis of Insl5 and Insl6 genes and verification of interactions between Pelota and its putative interacting proteins = Funktionelle Analyse der Insl5- und Insl6-Gene und Bestätigung der Interaktion von Pelota und dessen putativen Interaktionspartnern Preview this item
ClosePreview this item
Checking...

Functional analysis of Insl5 and Insl6 genes and verification of interactions between Pelota and its putative interacting proteins = Funktionelle Analyse der Insl5- und Insl6-Gene und Bestätigung der Interaktion von Pelota und dessen putativen Interaktionspartnern

Author: Ozanna Burnicka-Turek
Publisher: Göttingen Niedersächsische Staats- und Universitätsbibliothek
Edition/Format:   Computer file : English
Summary:
The aims of the study were to determinate expression and function of two members of insulin like family, namely Insl5 and Insl6 and to verify the interactions between PELO and its putative partners CDK2AP1, EIF3G and SRPX. To investigate the consequence of Insl5 inactivation, Insl5-deficient mice on the hybrid C57BL/Jx129/Sv and inbred 129/Sv genetic background have been analysed. This study shown, that the absence  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

 

Find a copy online

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Material Type: Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ozanna Burnicka-Turek
OCLC Number: 837031695
Description: Online-Ressource (PDF-Datei: xx S., x MB) Ill., graph. Darst.
Other Titles: Funktionelle Analyse der Insl5- und Insl6-Gene und Bestätigung der Interaktion von Pelota und dessen putativen Interaktionspartnern
Responsibility: vorgelegt von Ozanna Burnicka-Turek

Abstract:

The aims of the study were to determinate expression and function of two members of insulin like family, namely Insl5 and Insl6 and to verify the interactions between PELO and its putative partners CDK2AP1, EIF3G and SRPX. To investigate the consequence of Insl5 inactivation, Insl5-deficient mice on the hybrid C57BL/Jx129/Sv and inbred 129/Sv genetic background have been analysed. This study shown, that the absence of Insl5 in both genetic backgrounds does not significantly affect the health. The most interesting differences between Insl5-/- and wild type mice on the hybrid genetic background were observed in behaviours, especial in nociceptive behaviours. Thus, Insl5-/- mice show delayed latency for antinociceptive behaviour and show faster paw withdraw latency potentially due to impairment of descending inhibitory antinociceptive inputs to the spinal cord. These results suggest that the Insl5-deficiency impairs neuronal pathways involved in the central mediation of pain or maintenance of the balance of spinal excitatory and inhibitory processes ...

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/837031695> # Functional analysis of Insl5 and Insl6 genes and verification of interactions between Pelota and its putative interacting proteins = Funktionelle Analyse der Insl5- und Insl6-Gene und Bestätigung der Interaktion von Pelota und dessen putativen Interaktionspartnern
    a bgn:ComputerFile, schema:CreativeWork ;
   library:oclcnum "837031695" ;
   library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/1220320209#Place/gottingen> ; # Göttingen
   library:placeOfPublication <http://id.loc.gov/vocabulary/countries/gw> ;
   schema:about <http://dewey.info/class/610/> ;
   schema:alternateName "Funktionelle Analyse der Insl5- und Insl6-Gene und Bestätigung der Interaktion von Pelota und dessen putativen Interaktionspartnern" ;
   schema:creator <http://experiment.worldcat.org/entity/work/data/1220320209#Person/burnicka_turek_ozanna> ; # Ozanna Burnicka-Turek
   schema:datePublished "2009" ;
   schema:exampleOfWork <http://worldcat.org/entity/work/id/1220320209> ;
   schema:inLanguage "en" ;
   schema:name "Functional analysis of Insl5 and Insl6 genes and verification of interactions between Pelota and its putative interacting proteins = Funktionelle Analyse der Insl5- und Insl6-Gene und Bestätigung der Interaktion von Pelota und dessen putativen Interaktionspartnern" ;
   schema:productID "837031695" ;
   schema:publication <http://www.worldcat.org/title/-/oclc/837031695#PublicationEvent/gottingenniedersachsische_staats_und_universitatsbibliothek> ;
   schema:publisher <http://experiment.worldcat.org/entity/work/data/1220320209#Agent/niedersachsische_staats_und_universitatsbibliothek> ; # Niedersächsische Staats- und Universitätsbibliothek
   schema:url <http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-2285-7> ;
   schema:url <http://resolver.sub.uni-goettingen.de/purl/?webdoc-2285> ;
   umbel:isLike <http://d-nb.info/1042519641> ;
   wdrs:describedby <http://www.worldcat.org/title/-/oclc/837031695> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/1220320209#Agent/niedersachsische_staats_und_universitatsbibliothek> # Niedersächsische Staats- und Universitätsbibliothek
    a bgn:Agent ;
   schema:name "Niedersächsische Staats- und Universitätsbibliothek" ;
    .

<http://experiment.worldcat.org/entity/work/data/1220320209#Person/burnicka_turek_ozanna> # Ozanna Burnicka-Turek
    a schema:Person ;
   schema:familyName "Burnicka-Turek" ;
   schema:givenName "Ozanna" ;
   schema:name "Ozanna Burnicka-Turek" ;
    .

<http://www.worldcat.org/title/-/oclc/837031695>
    a genont:InformationResource, genont:ContentTypeGenericResource ;
   schema:about <http://www.worldcat.org/oclc/837031695> ; # Functional analysis of Insl5 and Insl6 genes and verification of interactions between Pelota and its putative interacting proteins = Funktionelle Analyse der Insl5- und Insl6-Gene und Bestätigung der Interaktion von Pelota und dessen putativen Interaktionspartnern
   schema:dateModified "2017-12-24" ;
   void:inDataset <http://purl.oclc.org/dataset/WorldCat> ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.