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Functional analysis of the mouse RBBP6 gene using interference RNA.

Author: Ashley Pretorius
Publisher: 2007.
Dissertation: Thesis (Ph. D.)--University of the Western Cape, 2007.
Edition/Format:   Thesis/dissertation : Thesis/dissertation : Manuscript   Archival Material : English
Database:WorldCat
Summary:
The aim of this thesis was to investigate the cellular role of the mouse RBBP6 gene using the interference RNA (RNAi) gene targeting technology and also to understand the relevance of two promoters for the RBBP6 gene. Genetic analysis showed the presence of two promoters for RBBP6 namely Promoter 0 (P0) and Promoter 1 (P1) both being responsible for the different RBBP6 transcripts. The Enhanced Green Fluorescent  Read more...
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Material Type: Thesis/dissertation, Manuscript, Internet resource
Document Type: Book, Archival Material, Internet Resource
All Authors / Contributors: Ashley Pretorius
OCLC Number: 644463128
Description: x, 94 leaves ; 30 cm.

Abstract:

The aim of this thesis was to investigate the cellular role of the mouse RBBP6 gene using the interference RNA (RNAi) gene targeting technology and also to understand the relevance of two promoters for the RBBP6 gene. Genetic analysis showed the presence of two promoters for RBBP6 namely Promoter 0 (P0) and Promoter 1 (P1) both being responsible for the different RBBP6 transcripts. The Enhanced Green Fluorescent Protein (EGFP) and the Red Fluorescent Protein (DsRed1) were both placed under the transcriptional control of P0 and P1. Promoter activities were measured using FACS and Real-Time qRT-PCR. The results showed P0 to have a higher level of transcriptional activity than P1 before and after camptothecin-induced apoptosis.

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