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Fundamental Bioengineering.

Author: John Villadsen
Publisher: [Place of publication not identified] : John Wiley and Sons, Inc., 2015.
Series: Advanced biotechnology.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
A thorough introduction to the basics of bioengineering, with a focus on applications in the emerging "white" biotechnology industry. As such, this latest volume in the "Advanced Biotechnology" series covers the principles for the design and analysis of industrial bioprocesses as well as the design of bioremediation systems, and several biomedical applications. No fewer than seven chapters introduce stoichiometry,  Read more...
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Additional Physical Format: Print version:
Villadsen, John.
Fundamental Bioengineering.
(OCoLC)917355059
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: John Villadsen
ISBN: 3527697462 9783527697465 9783527697441 3527697446 3527336745 9783527336746
OCLC Number: 925294466
Description: 1 online resource.
Contents: Related Titles; Title Page; Copyright; List of Contributors; About the Series Editors; Chapter 1: Introduction and Overview; Part One: Fundamentals of Bioengineering; Chapter 2: Experimentally Determined Rates of Bio-Reactions; Summary; 2.0 Introduction; 2.1 Mass Balances for a CSTR Operating at Steady State; 2.2 Operation of the Steady-State CSTR; References; Chapter 3: Redox Balances and Consistency Check of Experiments; Summary; 3.1 Black-Box Stoichiometry Obtained in a CSTR Operated at Steady State; 3.2 Calculation of Stoichiometric Coefficients by Means of a Redox Balance. 3.3 Applications of the Redox Balance3.4 Composition of the Biomass X; 3.5 Combination of Black-Box Models; 3.6 Application of Carbon and Redox Balances in Bio-Remediation Processes; References; Chapter 4: Primary Metabolic Pathways and Metabolic Flux Analysis; Summary; 4.0 Introduction; 4.1 Glycolysis; 4.2 Fermentative Metabolism: Regenerating the NAD+ Lost in Glycolysis; 4.3 The TCA Cycle: Conversion of Pyruvate to NADH + FADH2, to Precursors or Metabolic Products; 4.4 NADPH and Biomass Precursors Produced in the PP Pathway. 4.5 Oxidative Phosphorylation: Production of ATP from NADH (FADH2) in Aerobic Fermentation4.6 Summary of the Biochemistry of Primary Metabolic Pathways; 4.7 Metabolic Flux Analysis Discussed in Terms of Substrate to Product Pathways; 4.8 Metabolic Flux Analysis Discussed in Terms of Individual Pathway Rates in the Network; 4.9 Propagation of Experimental Errors in MFA; 4.10 Conclusions; References; Chapter 5: A Primer to 13C Metabolic Flux Analysis; Summary; 5.1 Introduction; 5.2 Input and Output Data of 13C MFA; 5.3 A Brief History of 13C MFA; 5.4 An Illustrative Toy Example. 5.5 The Atom Transition Network5.6 Isotopomers and Isotopomer Fractions; 5.7 The Isotopomer Transition Network; 5.8 Isotopomer Labeling Balances; 5.9 Simulating an Isotope Labeling Experiment; 5.10 Isotopic Steady State; 5.11 Flux Identifiability; 5.12 Measurement Models; 5.13 Statistical Considerations; 5.14 Experimental Design; 5.15 Exchange Fluxes; 5.16 Multidimensional Flux Identifiability; 5.17 Multidimensional Flux Estimation; 5.18 The General Parameter Fitting Procedure; 5.19 Multidimensional Statistics; 5.20 Multidimensional Experimental Design. 5.21 The Isotopically Nonstationary Case5.22 Some Final Remarks on Network Specification; 5.23 Algorithms and Software Frameworks for 13C MFA; Glossary; References; Chapter 6: Genome-Scale Models; Summary; 6.1 Introduction; 6.2 Reconstruction Process of Genome-Scale Models; 6.3 Genome-Scale Model Prediction; 6.4 Genome-Scale Models of Prokaryotes; 6.5 Genome-Scale Models of Eukaryotes; 6.6 Integration of Polyomic Data into Genome-Scale Models; Acknowledgment; References; Chapter 7: Kinetics of Bio-Reactions; Summary.
Series Title: Advanced biotechnology.

Abstract:

A comprehensive source of information about the fundamentals of bioengineering as part of the book series "Advanced Biotechnology", edited by Sang Yup Lee, Jens Nielsen and Gregory Stephanopoulos.  Read more...

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