skip to content
G protein coupled receptors : modeling, activation, interactions and virtual screening. Preview this item
ClosePreview this item
Checking...

G protein coupled receptors : modeling, activation, interactions and virtual screening.

Author: P Michael Conn
Publisher: Burlington : Elsevier Science, 2013.
Edition/Format:  eBook : Document : EnglishView all editions and formats
Summary:
<Ul> <ul> This new volume of <i>Methods in Enzymology</i> continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation. </ul></ul><br><br><ul>  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Conn, P. Michael.
G Protein Coupled Receptors : Modeling, Activation, Interactions and Virtual Screening.
Burlington : Elsevier Science, ©2013
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: P Michael Conn
ISBN: 9780124079441 012407944X
OCLC Number: 830163808
Description: 1 online resource (541 pages)
Contents: Front Cover ; G Protein Coupled Receptors: Modeling, Activation, Interactions and Virtual Screening; Copyright; Contents; Contributors; Preface; Methods in Enzymology; Chapter One: The Protein Local Optimization Program and G-Protein-Coupled Receptors: Loop Restoration and Applications to ...; 1. Introduction; 2. PLOP Performance for Loop Prediction; 3. PLOP and GPCRs; 4. Loop Prediction with the Single-Residue Library; 4.1. Single-loop prediction; 4.1.1. The buildup stage; 4.1.2. The closure stage; 4.1.3. The clustering stage; 4.1.4. Optimization and scoring stage; 4.2. Full-loop prediction. 4.2.1. Initial stage (Init)4.2.2. First constrained refinement stage (Ref1); 4.2.3. The fixed stages (Fix1, Fix2,, Fixn); 4.2.4. Second constrained refinement stage; 5. Loop Prediction with the Dipeptide Library; 6. Hierarchical Loop Prediction with Surrounding Side Chain Optimization; 6.1. Removal of side chains during backbone sampling; 6.2. Simultaneous optimization of side chains in both loop and nearby regions; 7. Additional Sampling Methods; 7.1. Prediction of loops containing small helical secondary structure; 7.2. Phase space partitioning method. 8. VSGB 2.0: The Newest Energy Model Incorporated into PLOP8.1. Hydrogen bonding correction (EHB); 8.2. Self-contact correction; 8.3. <U+0073>-<U+0073> packing correction; 8.4. Hydrophobic term; 9. Conclusions; Acknowledgments; References; Chapter Two: Modeling Active GPCR Conformations; 1. Introduction; 2. General Approaches; 2.1. Homology modeling; 2.2. De novo methods; 3. Agonist-Induced Activation; 4. Simulation Methods; 4.1. The activation pathway; 4.2. Protonation; 4.3. Parameters; 4.4. Oligomerization and activation; 5. Microswitches; 5.1. DRY and the ionic lock; 5.2. The rotamer toggle switch. 5.3. EL26. Biophysical Restraints; 7. Virtual Screening; 8. Class B GPCRs; Acknowledgments; References; Chapter Three: Molecular Modeling of Adenosine Receptors; 1. Introduction; 2. Adenosine A2a Receptor; 2.1. X-ray structures; 2.2. Receptor activation; 3. Receptor Modeling; 3.1. Building adenosine receptor models; 3.2. Homology modeling; 3.2.1. Alignment; 3.2.2. Modeling; 3.2.3. Detailed procedure of the alignment and modeling steps; 3.2.4. Optimization; 3.2.5. Detailed procedure of the optimization step; 3.3. MM/PBSA; 3.4. Validation methods; 3.5. Receptor oligomerization. 3.5.1. Adenosine receptor homo- and heterooligomerization3.5.2. Procedure for modeling an AA2AR dimer; 4. Summary; References; Chapter Four: Predicting G-Protein-Coupled Receptors Families Using Different Physiochemical Properties and Pseudo Amino ...; 1. Introduction; 1.1. G-protein-coupled receptors; 1.2. Pharmacological and phylogenetic classification of GPCRs; 1.3. Classification by alignment-independent classifiers; 2. GPCRs Prediction; 2.1. Feature extraction strategies; 2.1.1. Amphiphilic Pseudo amino acid composition; 2.1.2. Wavelet-based MSE.

Abstract:

<Ul> <ul> This new volume of <i>Methods in Enzymology</i> continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation. </ul></ul><br><br><ul> <ul></ul><li>Continues the legacy of this premier serial with quality chapters authored by leaders in the field </li><li>Covers G protein coupled receptors </li><li>Contains chapters on such topics as GPCR modelling, interactions with other.

Reviews

User-contributed reviews

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/830163808> # G protein coupled receptors : modeling, activation, interactions and virtual screening.
    a schema:CreativeWork, schema:MediaObject, schema:Book ;
    library:oclcnum "830163808" ;
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/3375741977#Place/burlington> ; # Burlington
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/vtu> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/3375741977#Topic/science_life_sciences_biochemistry> ; # SCIENCE--Life Sciences--Biochemistry
    schema:about <http://experiment.worldcat.org/entity/work/data/3375741977#Topic/g_proteins_receptors> ; # G proteins--Receptors
    schema:about <http://dewey.info/class/574.19245/> ;
    schema:about <http://id.worldcat.org/fast/936832> ; # G proteins--Receptors
    schema:bookFormat schema:EBook ;
    schema:creator <http://viaf.org/viaf/84867021> ; # P Michael Conn
    schema:datePublished "2013" ;
    schema:description "Front Cover ; G Protein Coupled Receptors: Modeling, Activation, Interactions and Virtual Screening; Copyright; Contents; Contributors; Preface; Methods in Enzymology; Chapter One: The Protein Local Optimization Program and G-Protein-Coupled Receptors: Loop Restoration and Applications to ...; 1. Introduction; 2. PLOP Performance for Loop Prediction; 3. PLOP and GPCRs; 4. Loop Prediction with the Single-Residue Library; 4.1. Single-loop prediction; 4.1.1. The buildup stage; 4.1.2. The closure stage; 4.1.3. The clustering stage; 4.1.4. Optimization and scoring stage; 4.2. Full-loop prediction."@en ;
    schema:description "
      This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation.


Related Entities

<http://experiment.worldcat.org/entity/work/data/3375741977#Agent/elsevier_science> # Elsevier Science
    a bgn:Agent ;
    schema:name "Elsevier Science" ;
    .

<http://experiment.worldcat.org/entity/work/data/3375741977#Topic/science_life_sciences_biochemistry> # SCIENCE--Life Sciences--Biochemistry
    a schema:Intangible ;
    schema:name "SCIENCE--Life Sciences--Biochemistry"@en ;
    .

<http://id.worldcat.org/fast/936832> # G proteins--Receptors
    a schema:Intangible ;
    schema:name "G proteins--Receptors"@en ;
    .

<http://viaf.org/viaf/84867021> # P Michael Conn
    a schema:Person ;
    schema:familyName "Conn" ;
    schema:givenName "P. Michael" ;
    schema:name "P Michael Conn" ;
    .

<http://worldcat.org/entity/work/data/3375741977#CreativeWork/g_protein_coupled_receptors_modeling_activation_interactions_and_virtual_screening>
    a schema:CreativeWork ;
    rdfs:label "G Protein Coupled Receptors : Modeling, Activation, Interactions and Virtual Screening." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/830163808> ; # G protein coupled receptors : modeling, activation, interactions and virtual screening.
    .

<http://worldcat.org/isbn/9780124079441>
    a schema:ProductModel ;
    schema:isbn "012407944X" ;
    schema:isbn "9780124079441" ;
    .

<http://www.worldcat.org/title/-/oclc/830163808>
    a genont:InformationResource, genont:ContentTypeGenericResource ;
    schema:about <http://www.worldcat.org/oclc/830163808> ; # G protein coupled receptors : modeling, activation, interactions and virtual screening.
    schema:dateModified "2018-10-26" ;
    void:inDataset <http://purl.oclc.org/dataset/WorldCat> ;
    .

Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.

Cancel Forgot your password?