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Gastrointestinal mucosal repair and experimental therapeutics : a timely guide for researchers

Author: Chi-Hin Cho
Publisher: Basel Karger 2002
Series: Frontiers of gastrointestinal research, 25
Edition/Format:   Computer file : EnglishView all editions and formats
Summary:
Over the last decade, considerable progress has been made in understanding cellular and molecular mechanisms involved in gastrointestinal mucosal injury and repair. These findings provide the basis to identify the etiology and pathogenesis of various gut mucosal injury-related diseases and to develop new therapeutic approaches.The publication at hand is divided into three sections: Epithelial restitution, mucosal  Read more...
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Details

Material Type: Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Chi-Hin Cho
ISBN: 9783318008210 3318008214
OCLC Number: 837653738
Description: Online-Ressource.
Series Title: Frontiers of gastrointestinal research, 25
Responsibility: vol. ed.: C.-H. Cho; J.-Y. Wang

Abstract:

Over the last decade, considerable progress has been made in understanding cellular and molecular mechanisms involved in gastrointestinal mucosal injury and repair. These findings provide the basis to identify the etiology and pathogenesis of various gut mucosal injury-related diseases and to develop new therapeutic approaches.The publication at hand is divided into three sections: Epithelial restitution, mucosal repair and ulcer healing, and experimental therapeutics. The first part highlights the early rapid mucosal restitution, focussing on the roles of extracellular matrix, cytoskeleton, cytokines, Ca2+ signaling, polyamines, and the protein kinase C / DAG pathways. The next section deals with aspects of chronic mucosal healing, concentrating on the roles of primary response gene expression, angiogenesis and angiogenic growth factors, platelets, and the mechanisms of cell renewal after injury in special circumstances. The last part explores new therapeutic approaches, stressing potential clinical applications of nitric oxide-releasing agents, polysaccharides, nitric oxide synthase modulators, growth factors, prostaglandins, and cyclooxygenase inhibitors.Covering the current state-of-the-art findings relevant to gut mucosal injury and repair as well as providing the underlying conceptual basis and knowledge regarding experimental therapeutics for gastrointestinal mucosal injury-related diseases, this publication will be a timely guide for investigators working in the field

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