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Gene discovery for disease models

Author: Weikuan Gu
Publisher: Hoboken, N.J. : Wiley, ©2011.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:

This book provides readers with new paradigms on the mutation discovery in the post-genome era. The completion of human and other genome sequencing, along with other new technologies, such as  Read more...

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Document Type: Book
All Authors / Contributors: Weikuan Gu
ISBN: 9780470499467 047049946X
OCLC Number: 646388483
Description: xiii, 537 pages, [16] pages of plates : illustrations (some color) ; 25 cm
Contents: Introduction : gene discovery-from positional cloning to genomic cloning --
High throughput gene expression analysis and the identification of expression QTLs --
DNA methylation in the pathogenesis of autoimmunity --
Ccell-based analysis with microfluidic chip --
Missing dimension : protein turnover rate measurement in gene discovery --
Bioinformatics tools for the prediction of gene function --
Determination of genomic locations of targeted genetic loci --
Mutation discovery using high throughput mutation screening technology --
Candidate screening through gene expression profile --
Candidate screening through high-density SNP array --
Gene discovery through direct genome sequencing --
Candidate screening through bioinformatics tools --
Using an integrative strategy to identify mutations --
Determination of the function of a mutant in a gene --
Confirmation of a mutation by multiple molecular approaches --
Confirmation of a mutation by microRNA --
Confirmation of function of a gene by translational approaches --
Confirmation of single nucleotide mutations --
Initial identification and confirmation of a QTL gene --
Gene discovery of crop diseases in the post genome era --
Impact of whole genome genetic element analysis on gene discovery of disease models --
Impact of whole genome protein analysis on gene discovery of disease models.
Responsibility: edited by Weikuan Gu and Yongjun Wang.

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