skip to content
Gene discovery for disease models Preview this item
ClosePreview this item
Checking...

Gene discovery for disease models

Author: Weikuan Gu
Publisher: Hoboken, N.J. : Wiley, ©2011.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book provides readers with new paradigms on the mutation discovery in the postgenome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that âThe availability of an annotated mouse  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Gene discovery for disease models.
Hoboken, N.J. : Wiley, ©2011
(DLC) 2010028355
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Weikuan Gu
ISBN: 9780470933947 0470933941 9780470933930 0470933933 128298974X 9781282989740
OCLC Number: 708563222
Description: 1 online resource (xiii, 537 pages, [15] pages of plates) : color illustrations
Contents: Introduction : gene discovery-from positional cloning to genomic cloning --
High throughput gene expression analysis and the identification of expression QTLs --
DNA methylation in the pathogenesis of autoimmunity --
Ccell-based analysis with microfluidic chip --
Missing dimension : protein turnover rate measurement in gene discovery --
Bioinformatics tools for the prediction of gene function --
Determination of genomic locations of targeted genetic loci --
Mutation discovery using high throughput mutation screening technology --
Candidate screening through gene expression profile --
Candidate screening through high-density SNP array --
Gene discovery through direct genome sequencing --
Candidate screening through bioinformatics tools --
Using an integrative strategy to identify mutations --
Determination of the function of a mutant in a gene --
Confirmation of a mutation by multiple molecular approaches --
Confirmation of a mutation by microRNA --
Confirmation of function of a gene by translational approaches --
Confirmation of single nucleotide mutations --
Initial identification and confirmation of a QTL gene --
Gene discovery of crop diseases in the post genome era --
Impact of whole genome genetic element analysis on gene discovery of disease models --
Impact of whole genome protein analysis on gene discovery of disease models.
Responsibility: edited by Weikuan Gu.

Abstract:

This book provides readers with new paradigms on the mutation discovery in the post-genome era. The completion of human and other genome sequencing, along with other new technologies, such as  Read more...

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.

Similar Items

Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/708563222> # Gene discovery for disease models
    a schema:Book, schema:MediaObject, schema:CreativeWork ;
    library:oclcnum "708563222" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/nju> ;
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/1088842914#Place/hoboken_n_j> ; # Hoboken, N.J.
    schema:about <http://id.worldcat.org/fast/940009> ; # Genetic disorders
    schema:about <http://id.worldcat.org/fast/940228> ; # Genomics
    schema:about <http://experiment.worldcat.org/entity/work/data/1088842914#Topic/medical_genetics> ; # MEDICAL--Genetics
    schema:about <http://experiment.worldcat.org/entity/work/data/1088842914#Topic/health_&_fitness_diseases_genetic> ; # HEALTH & FITNESS--Diseases--Genetic
    schema:about <http://id.worldcat.org/fast/1014133> ; # Medical genetics
    schema:about <http://dewey.info/class/616.042/e22/> ;
    schema:about <http://id.worldcat.org/fast/1031152> ; # Mutation (Biology)
    schema:bookFormat schema:EBook ;
    schema:contributor <http://viaf.org/viaf/125734882> ; # Weikuan Gu
    schema:copyrightYear "2011" ;
    schema:datePublished "2011" ;
    schema:description "This book provides readers with new paradigms on the mutation discovery in the postgenome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that âThe availability of an annotated mouse genome sequence now provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from genetic mapping to identification of candidate genes, and the experimental process is reduced to PCR amplification and sequencing of exons and other conserved elements in the candidate interval. With this streamlined protocol, it is anticipated that many decadesold mouse mutants will be understood precisely at the DNA level in the near future.â? The implication of such a statement should be similar to the identification of mutated genes from human diseases and animal models, when genome sequencing is completed for them. More than five years have passed, but genes in many human diseases and animal models have not yet been identified. In some cases, the identification of the mutated genes has been a bottleneck, because the genetic mechanism holds the key to understand the basis of the diseases. However, an integrative strategy, which is a combination of genetic mapping, genome resources, bioinformatics tools, and high throughput technologies, has been developed and tested. The classic paradigm of positional cloning has evolved with completely new concepts of genomic cloning and protocols. This book describes new concepts of gene discovery in the postgenome era and the use of streamlined protocols to identify genes of interest. This book helps identify not only large insertions/deletions but also single nucleotide mutations or polymorphisms that regulate quantitative trait loci (QTL)."@en ;
    schema:description "Introduction : gene discovery-from positional cloning to genomic cloning -- High throughput gene expression analysis and the identification of expression QTLs -- DNA methylation in the pathogenesis of autoimmunity -- Ccell-based analysis with microfluidic chip -- Missing dimension : protein turnover rate measurement in gene discovery -- Bioinformatics tools for the prediction of gene function -- Determination of genomic locations of targeted genetic loci -- Mutation discovery using high throughput mutation screening technology -- Candidate screening through gene expression profile -- Candidate screening through high-density SNP array -- Gene discovery through direct genome sequencing -- Candidate screening through bioinformatics tools -- Using an integrative strategy to identify mutations -- Determination of the function of a mutant in a gene -- Confirmation of a mutation by multiple molecular approaches -- Confirmation of a mutation by microRNA -- Confirmation of function of a gene by translational approaches -- Confirmation of single nucleotide mutations -- Initial identification and confirmation of a QTL gene -- Gene discovery of crop diseases in the post genome era -- Impact of whole genome genetic element analysis on gene discovery of disease models -- Impact of whole genome protein analysis on gene discovery of disease models."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/1088842914> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isSimilarTo <http://worldcat.org/entity/work/data/1088842914#CreativeWork/gene_discovery_for_disease_models> ;
    schema:name "Gene discovery for disease models"@en ;
    schema:productID "708563222" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/708563222#PublicationEvent/hoboken_n_j_wiley_2011> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/1088842914#Agent/wiley> ; # Wiley
    schema:url <http://site.ebrary.com/lib/macewan/Doc?id=10441397> ;
    schema:url <http://www.myilibrary.com?id=298974> ;
    schema:url <http://ebookcentral.proquest.com/lib/concordiaab-ebooks/detail.action?docID=661512> ;
    schema:url <http://site.ebrary.com/lib/rdcollege/Doc?id=10441397> ;
    schema:url <http://ezproxy.agpc.talonline.ca:80/login?url=http://site.ebrary.com/lib/gprc/Doc?id=10441397> ;
    schema:url <http://gold.worcester.edu/login?url=http://site.ebrary.com/lib/worcesteruniv/Doc?id=10441397> ;
    schema:url <http://nbn-resolving.de/urn:nbn:de:101:1-201412128674> ;
    schema:url <https://ebookcentral.proquest.com/choice/publicfullrecord.aspx?p=661512> ;
    schema:url <https://ebookcentral.proquest.com/lib/ualberta/detail.action?docID=661512> ;
    schema:url <http://www.myilibrary.com?id=298974&ref=toc> ;
    schema:url <http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=517585> ;
    schema:url <http://nbn-resolving.de/urn:nbn:de:101:1-2015021511370> ;
    schema:url <http://site.ebrary.com/id/10441397> ;
    schema:url <http://d-nb.info/1063784549/34> ;
    schema:url <http://d-nb.info/1067031596/34> ;
    schema:url <http://dx.doi.org/10.1002/9780470933947> ;
    schema:url <http://iclibezp1.cc.ic.ac.uk/login?url=https://onlinelibrary.wiley.com/doi/book/10.1002/9780470933947> ;
    schema:url <http://site.ebrary.com/lib/concordiaab/Doc?id=10441397> ;
    schema:url <http://ebookcentral.proquest.com/lib/rdc/detail.action?docID=661512> ;
    schema:url <https://ebookcentral.proquest.com/lib/stanford-ebooks/detail.action?docID=661512> ;
    schema:url <http://catalogimages.wiley.com/images/db/jimages/9780470499467.jpg> ;
    schema:url <http://public.eblib.com/choice/publicfullrecord.aspx?p=661512> ;
    schema:url <http://ebookcentral.proquest.com/lib/gprc-ebooks/detail.action?docID=661512> ;
    schema:url <http://public.ebookcentral.proquest.com/choice/publicfullrecord.aspx?p=661512> ;
    schema:url <http://ebookcentral.proquest.com/lib/macewan-ebooks/detail.action?docID=661512> ;
    schema:url <https://onlinelibrary.wiley.com/doi/book/10.1002/9780470933947> ;
    schema:workExample <http://worldcat.org/isbn/9781282989740> ;
    schema:workExample <http://worldcat.org/isbn/9780470933930> ;
    schema:workExample <http://worldcat.org/isbn/9780470933947> ;
    umbel:isLike <http://d-nb.info/1067031596> ;
    umbel:isLike <http://d-nb.info/1063784549> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/708563222> ;
    .


Related Entities

<http://ebookcentral.proquest.com/lib/concordiaab-ebooks/detail.action?docID=661512>
    rdfs:comment "from Ebook Central Academic Complete" ;
    rdfs:comment "(Unlimited Concurrent Users)" ;
    .

<http://ebookcentral.proquest.com/lib/gprc-ebooks/detail.action?docID=661512>
    rdfs:comment "from Ebook Central Academic Complete" ;
    rdfs:comment "(Unlimited Concurrent Users)" ;
    .

<http://ebookcentral.proquest.com/lib/macewan-ebooks/detail.action?docID=661512>
    rdfs:comment "from Ebook Central Academic Complete" ;
    rdfs:comment "(Unlimited Concurrent Users)" ;
    .

<http://ebookcentral.proquest.com/lib/rdc/detail.action?docID=661512>
    rdfs:comment "from Ebook Central Academic Complete" ;
    rdfs:comment "(Unlimited Concurrent Users)" ;
    .

<http://experiment.worldcat.org/entity/work/data/1088842914#Place/hoboken_n_j> # Hoboken, N.J.
    a schema:Place ;
    schema:name "Hoboken, N.J." ;
    .

<http://experiment.worldcat.org/entity/work/data/1088842914#Topic/health_&_fitness_diseases_genetic> # HEALTH & FITNESS--Diseases--Genetic
    a schema:Intangible ;
    schema:name "HEALTH & FITNESS--Diseases--Genetic"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1088842914#Topic/medical_genetics> # MEDICAL--Genetics
    a schema:Intangible ;
    schema:name "MEDICAL--Genetics"@en ;
    .

<http://id.worldcat.org/fast/1014133> # Medical genetics
    a schema:Intangible ;
    schema:name "Medical genetics"@en ;
    .

<http://id.worldcat.org/fast/1031152> # Mutation (Biology)
    a schema:Intangible ;
    schema:name "Mutation (Biology)"@en ;
    .

<http://id.worldcat.org/fast/940009> # Genetic disorders
    a schema:Intangible ;
    schema:name "Genetic disorders"@en ;
    .

<http://id.worldcat.org/fast/940228> # Genomics
    a schema:Intangible ;
    schema:name "Genomics"@en ;
    .

<http://site.ebrary.com/lib/macewan/Doc?id=10441397>
    rdfs:comment "from ebrary" ;
    rdfs:comment "(Unlimited Concurrent Users)" ;
    .

<http://viaf.org/viaf/125734882> # Weikuan Gu
    a schema:Person ;
    schema:familyName "Gu" ;
    schema:givenName "Weikuan" ;
    schema:name "Weikuan Gu" ;
    .

<http://worldcat.org/entity/work/data/1088842914#CreativeWork/gene_discovery_for_disease_models>
    a schema:CreativeWork ;
    rdfs:label "Gene discovery for disease models." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/708563222> ; # Gene discovery for disease models
    .

<http://worldcat.org/isbn/9780470933930>
    a schema:ProductModel ;
    schema:isbn "0470933933" ;
    schema:isbn "9780470933930" ;
    .

<http://worldcat.org/isbn/9780470933947>
    a schema:ProductModel ;
    schema:isbn "0470933941" ;
    schema:isbn "9780470933947" ;
    .

<http://worldcat.org/isbn/9781282989740>
    a schema:ProductModel ;
    schema:isbn "128298974X" ;
    schema:isbn "9781282989740" ;
    .

<https://ebookcentral.proquest.com/lib/stanford-ebooks/detail.action?docID=661512>
    rdfs:comment "Available to Stanford-affiliated users." ;
    .

<https://ebookcentral.proquest.com/lib/ualberta/detail.action?docID=661512>
    rdfs:comment "from Ebook Central Academic Complete" ;
    rdfs:comment "(Unlimited Concurrent Users)" ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.