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Gene targeting : a practical approach

Author: Alexandra L Joyner
Publisher: Oxford ; New York : Oxford University Press, 2000.
Series: Practical approach series.
Edition/Format:   Print book : English : 2nd edView all editions and formats
Summary:
"This new edition of Gene Targeting: A Practical Approach contains a remarkable collection of state-of-the-art protocols as well as thoughtful discussion of how to design a new mouse mutation and analyse the resulting phenotype to maximise the information gained. The techniques described for gene targeting in mouse ES cells, are equally applicable for gene targeting in other tissue culture cells, including human  Read more...
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Genre/Form: Laboratory Manuals
Laboratory manuals
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Alexandra L Joyner
ISBN: 0199637938 9780199637935 019963792X 9780199637928
OCLC Number: 41649667
Description: xviii, 293 pages : illustrations ; 24 cm.
Contents: Gene targeting, principles, and practice in mammalian cells / Paul Hasty, Alejandro Abuin, and Allan Bradley --
Site-specific recombination in cells and mice / Susan M. Dymecki --
Production of targeted embryonic stem cell clones / Michael P. Matise, Wojtek Auerbach and Alexandra L. Joyner --
Production of chimeras by blastocyst and morula injection of targeted ES cells / Virginia Papaioannou and Randall Johnson --
Production and analysis of ES cell aggregation chimeras / Andreas Nagy and Janet Rossant --
Gene trap strategies in ES cells / Wolfgang Wurst and Achim Gossler --
Classical genetics and gene targeting / Scott Bultman and Terry Magnuson.
Series Title: Practical approach series.
Responsibility: edited by Alexandra L. Joyner.
More information:

Abstract:

Gene targeting is the introduction of genomic DNA into a specific location on the host genome. It is used to make a variety of specific mutations so the phenotypic consequences of specific genetic  Read more...

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" ... a collection of state-of-the-art protocols" Cambridge Scientific Abstracts "The book can be warmly recommended as a valuable advisor for researchers in the fields of mouse genetics and cell Read more...

 
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