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Genetic load, its biological and conceptual aspects

Author: Bruce Wallace
Publisher: Englewood Cliffs, N.J. : Prentice-Hall, ©1970.
Series: Concepts of modern biology series.
Edition/Format:   Print book : EnglishView all editions and formats
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Additional Physical Format: Online version:
Wallace, Bruce, 1920-
Genetic load, its biological and conceptual aspects.
Englewood Cliffs, N.J. : Prentice-Hall, ©1970
(OCoLC)610590924
Document Type: Book
All Authors / Contributors: Bruce Wallace
ISBN: 0133511979 9780133511970
OCLC Number: 50642
Description: xi, 116 pages : illustrations ; 24 cm.
Contents: I. The biological aspects of genetic load : 1. Expressed variation in randomly mating populations --
2. Genetic variation in homozygous populations --
3. Origin and maintenance of genetic variation : Rates of mutation ; Abnormal chromosome numbers in man ; Chromosomal aberrations ; Selection versus mutation ; Variation by selection --
4. The role of genetic variation : Genetic diversity and response to selection ; Adaptation ; Evolution ; The immediate effect of diversity on populations II. The algebraic aspects of genetic load : 5. The Hardy-Weinberg equation : Zygotic frequencies ; Gene frequencies ; The Hardy-Weinberg proportions --
6. Mutation versus selection : Mutation ; Selection against deleterious genes ; Mutation versus selection --
7. Balanced Polymorphism : Marginal overdominance --
8. Genetic load : The mutational load ; The segregational load ; Frequency-dependent selections ; Other genetic loads --
9. Deductions based on load calculations : The effect on human populations of doubling the mutation rate ; The contribution of the "normal" allele to the segregational load ; The cost of natural selection ; The number of alleles that can be maintained by balanced polymorphisms ; Relative contributions of mutation and polymorphism to genetic loads: load ratios III. Population aspects of genetic load : 10. Mankind: a special case : Balanced polymorphism in man ; Differential reproduction in man ; A load-free population --
11. Population regulation : The growth of a laboratory population of Drosophila ; Objections to the above model of population regulation ; Absorbing new causes of death ; The statistics and dynamics of populations --
12. Genetic variation and equilibrium populations : The replacement of one allele by another in population ; Oscillating gene frequencies in polymorphic populations ; Genetic load and population ecology --
13. Hard and soft selection --
14. The limits of genetic variation ; 15. Responsibility for the segregational load --
16. Uncovering genetic load by inbreeding --
17. Concluding Remarks.
Series Title: Concepts of modern biology series.
Responsibility: Bruce Wallace.

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